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Production of the metabolite acetyl-CoA near specific regions of DNA modulates gene expression in mouse neurons during cellular differentiation and memory formation. See Article p.381
Droplet-like assemblies of RNA in cell nuclei are associated with certain neurodegenerative diseases. Experiments reveal that these assemblies become 'frozen' gels in cells, potentially explaining their toxicity. See Article p.243
Evolution favours the body form best adapted to the local environment, but it can also favour rare forms. Stickleback experiments reveal how these two selection forces can interact, and how this can limit population divergence. See Letter p.285
Reliably measuring global health is a huge challenge. Four papers published in 1997 laid foundations for future global-health estimates, but, despite subsequent advances, better integration of data systems and models is still needed.
The neighbourhoods of extremely bright astronomical objects called quasars in the early Universe have been incompletely probed. Observations suggest that these regions harbour some of the most massive known galaxies. See Letter p.457
The Hubbard model describes the behaviour of interacting quantum particles, but many of its properties remain unknown. A system of ultracold atoms could provide the key to determining the model's underlying physics. See Letter p.462
Genomic analysis of lung-tumour evolution has been used to create personalized blood tests that enable successful clinical monitoring for early signs of cancer relapse — a promising step on the road to precision medicine. See Article p.446
The use of genetically engineered T cells in the treatment of cancer is reviewed, with particular focus on anti-CD19 chimaeric antigen receptor therapy, providing a summary of past progress and current status, and potential future directions.
The geological record contains evidence of how Earth's climate responded to periodic changes in our planet's orbit and rotation. An investigation reveals how this record can be leveraged to constrain estimates of past climate dynamics.
Evolutionary trees constructed using both newly sequenced and previously available Zika virus genomes reveal how the recent outbreak arose in Brazil and spread across the Americas. See Letters p.401, p.406 & p.411
The development of a microscopy technique that enables observation of the interactions between six types of organelle, in 3D and over time, holds promise for improving our understanding of intracellular processes. See Letter p.162
New detectors for radio telescopes can map emissions from many different molecules simultaneously across interstellar clouds. One such pioneering study has probed a wide area of a star-forming cloud in the Orion constellation.
