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Aneuploid cancer cell lines show increased dependence on the spindle assembly complex (SAC); initially they are resistant to SAC perturbations, but over time they accumulate chromosomal aberrations that impair their fitness.
Cancer cells that have undergone whole-genome doubling are more reliant than their near-diploid counterparts on DNA-replication factors, the spindle-assembly checkpoint and a mitotic kinesin protein, KIF18A.
Trends in the rate of region- and sector-specific land-use greenhouse gas emissions in 1961–2017 show an acceleration of about 20% per decade after 2001.
X-ray diffraction measurements of solid carbon compressed to pressures of about two terapascals (approximately twenty million atmospheres) find that carbon retains a diamond structure even under these extreme conditions.
The global abundance of oceanic sharks and rays has decreased by 71% since 1970 and 24 species are threatened with extinction owing to a concomitant increase in fishing pressure.
Recordings of cells in the human dorsomedial prefrontal cortex identify a population of neurons that encode information about others’ beliefs and distinguish them from self-belief-related representations, providing insight into cellular-level processing underlying human theory of mind.
The genome of the biofuel crop switchgrass (Panicum virgatum) reveals climate–gene–biomass associations that underlie adaptation in nature and will facilitate improvements of the yield of this crop for bioenergy production.
Reanalysis of Holocene sea surface temperature records affirms the role of retreating ice and rising greenhouse gases in driving a steady increase in global temperatures over the past 12,000 years.
Data from ocean bottom seismometers show that the mantle transition zone beneath the equatorial Mid-Atlantic Ridge is thin and warm, which suggests more material transfer than previously thought.
Binding of METTL3 to chromatin is enriched over IAP family endogenous retroviral elements in mouse embryonic stem cells, helping to ensure the integrity of heterochromatin at these elements.
In many survivors of Ebola virus infection, antibody responses show long-term patterns of decline followed by restimulation, possibly owing to recrudescence of persisting virus.
Patients with mild COVID-19 show a pattern of interferon-stimulated gene (ISG) expression across all major cell types, but in patients with severe disease, antibodies block the production of these ISG-expressing cells.
Experimental deletion of the furin cleavage site of the SARS-CoV-2 spike protein highlights an important role for this site in infection and the need to consider this site when evaluating the neutralization activities of antibodies.
A reprogrammable mechanical metamaterial constructed of bistable unit cells that can be switched independently and reversibly between two stable states with distinct mechanical properties using magnetic actuation is demonstrated.
Modelling and remote sensing show that by the end of the twenty-first century, lake heatwaves will be several degrees Celsius warmer and some will be months longer, with potentially major adverse consequences for lake ecosystems.
A stable, low-temperature water–gas shift catalyst is achieved by crowding platinum atoms and clusters on α-molybdenum carbide; the crowding protects the support from oxidation that would cause catalyst deactivation.
A theoretical model, in vitro reconstitution and in vivo experimentation show that competition between droplet surface tension and membrane sheet instability dictates the form and function of autophagosomal membranes.
