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The histone acetyl transferase KAT2A (also known as GCN5) can also catalyse histone succinylation, with the α-KGDH complex providing a local source of succinyl-CoA.
The transcription factor Runx3 is identified as a central regulator of the development of tissue-resident memory CD8+ T cells, providing insights into the signals that promote T cell residency in non-lymphoid tissues and tumours.
A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition of its production can rescue vascular abnormalities in a mouse model of the disease.
The recently discovered theropod Halszkaraptor escuillei reveals a novel basal dromaeosaurid clade, and its adaptations that suggest a semi-aquatic predatory lifestyle add an additional ecomorphology to those developed by non-avian maniraptorans.
Triangulation of microbe–phenotype relationships is an effective method for reducing the noise inherent in microbiota studies and enabling identification of causal microbes of disease, which may be applicable to human microbiome studies.
Observations of a quasar at redshift 7.54, when the Universe was just five per cent of its current age, suggest that the Universe was significantly neutral at this epoch.
The formation of cellular adhesion complexes is important in normal and pathological cell activity, and is determined by the force imposed by the combined effect of the distribution of extracellular matrix molecules and substrate rigidity.
Amyloid-β peptide proteopathies disrupt mitochondria, and restoring mitochondrial proteostasis reduces protein aggregation in animal models of amyloid-β disease.
Methane fluxes from the stems of Amazonian floodplain trees indicate that the escape of soil gas through wetland trees is the dominant source of methane emissions in the Amazon basin.
The spectral variability of the blazar CTA 102 during a recent extreme outburst could be explained by a twisted, inhomogeneous jet containing regions of different orientations that vary in time.
Programmable quantum simulations of many-body systems are demonstrated using a reconfigurable array of 51 individually trapped cold atoms with strong, coherent interactions controlled via excitation to Rydberg states.
A modified Escherichia coli is used to demonstrate that semi-synthetic organisms can use non-natural hydrophobic base pairs to genetically encode for the incorporation of non-canonical amino acids into proteins.
Single-site isolated rhodium species anchored on zeolites or titanium dioxide are shown to catalyse the direct conversion of methane to methanol and acetic acid, using oxygen and carbon monoxide under mild conditions.
Many-body dynamical phases in an Ising-like quantum spin model with long-range interactions are observed by measuring correlations in single shots, using a quantum simulator composed of 53 qubits.
Halogen abundances in chondrites are 6 to 37 times lower than previously reported, which is consistent with the low abundances of these elements found in Earth.
Proteins expressed on the surfaces of erythrocytes infected with Plasmodium falciparum help the parasite to evade the host immune system by acting as ligands for immune inhibitory receptors and thereby downregulating the immune response.
Maternal age is found to be a major source of phenotypic variation in isogenic C. elegans populations living in a controlled environment, with the progeny of young mothers impaired for multiple fitness traits.
A genetically encoded platform can produce chiral organoboranes in bacteria with high turnover, enantioselectivity and chemoselectivity, and can be tuned and configured through DNA manipulation.
A 22-nucleotide fragment of a transfer RNA regulates translation by binding to the mRNA of a ribosomal protein and increasing its expression, and downregulation of the fragment in patient-derived liver tumour cells reduces tumour growth in mice.