Research articles

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  • An explicit theoretical construction of a metallic non-Fermi liquid ground state opens a route to attack long-standing problems such as the ‘strange metal’ phase of high-temperature superconductors.

    • Hong-Chen Jiang
    • Matthew S. Block
    • Matthew P. A. Fisher
  • Comparative analysis of the genomes of one mollusc (Lottia gigantea) and two annelids (Capitella teleta and Helobdella robusta) enable a more complete reconstruction of genomic features of the last common ancestors of protostomes, bilaterians and metazoans; against this conserved background they provide the first glimpse into lineage-specific evolution and diversity of the lophotrochozoans.

    • Oleg Simakov
    • Ferdinand Marletaz
    • Daniel S. Rokhsar
    Letter Open Access
  • Rare truncating mutations in the p53-inducible protein phosphatase PPM1D are shown to be associated with predisposition to breast cancer and ovarian cancer; notably, all of the mutations are mosaic in white blood cells but are not present in tumours, and probably have a gain-of-function effect.

    • Elise Ruark
    • Katie Snape
    • Nazneen Rahman
  • Fluorescence of iron ions induced by an X-ray laser allows the relative oscillator strength for Fe xvii emission to be determined; it is found to differ by 3.6σ from the best quantum mechanical calculations, suggesting that the poor agreement between prediction and observations of the brightest Fe xvii line is rooted in the quality of the underlying atomic wavefunctions used in the models.

    • S. Bernitt
    • G. V. Brown
    • J. R. Crespo López-Urrutia
  • Climate models predict that precipitation will increase in Antarctica, leading to potential ice mass gain and an offset to sea level rise, but here it is shown that enhanced snowfall on Antarctica is likely to increase ice discharge and thereby negate 30% to 65% of the snowfall-induced ice gain.

    • R. Winkelmann
    • A. Levermann
    • K. Frieler
  • A broadband, compact, all-electrically driven mid-infrared frequency comb based on a quantum cascade laser widens the scope of application of combs in this frequency range beyond that of sources which depend on a chain of optical components.

    • Andreas Hugi
    • Gustavo Villares
    • Jérôme Faist
  • Biomarker and stable isotopic analysis of lipid residues from perforated pottery vessels from sixth millennium bc Europe are consistent with these vessels having been used for making cheese, a low-lactose dairy product with digestion and storage advantages for the prehistoric lactose-intolerant farming communities.

    • Mélanie Salque
    • Peter I. Bogucki
    • Richard P. Evershed
  • A new interpretation of fossilized soils (palaeosols) suggests that at least some Ediacaran (625–542 million years ago) organisms lived on land; thus these Ediacaran fossils were not animals, but a fungus-dominated terrestrial biota that predated vascular plants by about 100 million years.

    • Gregory J. Retallack
  • Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat paradigm and in previously resilient mice that have been subjected to repeated social-defeat stress, and this effect is projection-pathway specific.

    • Dipesh Chaudhury
    • Jessica J. Walsh
    • Ming-Hu Han
  • A class of metal-free organic electroluminescent molecules is designed in which both singlet and triplet excitons contribute to light emission, leading to an intrinsic fluorescence efficiency greater than 90 per cent and an external electroluminescence efficiency comparable to that achieved in high-efficiency phosphorescence-based organic light-emitting diodes.

    • Hiroki Uoyama
    • Kenichi Goushi
    • Chihaya Adachi
  • An automated approach designing drug ligands to multi-target profiles (with a 75% prediction success rate) is experimentally validated by the invention of novel ligands tailored to the complex and physiologically-relevant goal of identifying drugs that can specifically target profiles of multiple proteins.

    • Jérémy Besnard
    • Gian Filippo Ruda
    • Andrew L. Hopkins
  • RNA-recognition elements are identified for the fragile-X-syndrome-associated RNA-binding protein FMRP, in addition to its target messenger RNAs; although many of FMRP gene targets discovered are involved in brain function and autism spectrum disorder, a proportion are also dysregulated in mouse ovaries, suggesting cross-regulation of signalling pathways in different tissues.

    • Manuel Ascano
    • Neelanjan Mukherjee
    • Thomas Tuschl
  • A Staphylococcus aureus leukotoxin targets cells expressing the chemokine receptor CCR5, a mechanism for the specificity of leukotoxins towards different immune cells.

    • Francis Alonzo III
    • Lina Kozhaya
    • Victor J. Torres
  • Single-molecule fluorescence microscopy techniques are used to elucidate features of the highly conserved protein-targeting machinery known as the signal recognition particle (SRP); the long SRP RNA is shown to be crucial for correct timing and precision of cargo handover to the protein-translocation machinery, a finding that could help to explain how other ribonucleosome complexes function during complex cellular processes.

    • Kuang Shen
    • Sinan Arslan
    • Shu-ou Shan