Cellular cross-talk, enzymatic catalysis and regulation of gene expression all depend on molecular recognition. A method that allows the design of proteins with desired recognition sites could thus be revolutionary. See Letter p.212
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
*This article and the paper under discussion1 were published online on 4 September 2013.
References
Tinberg, C. E. et al. Nature 501, 212–216 (2013).
Gebauer, M. & Skerra, A. Meth. Enzymol. 503, 157–188 (2012).
Gilbreth, R. N. & Koide, S. Curr. Opin. Struct. Biol. 22, 413–420 (2012).
Jiang, L. et al. Science 319, 1387–1391 (2008).
Siegel, J. B. et al. Science 329, 309–313 (2010).
Röthlisberger, D. et al. Nature 453, 190–195 (2008).
Privett, H. K. et al. Proc. Natl Acad. Sci. USA 109, 3790–3795 (2012).
Korendovych, I. V. et al. Org. Lett. 12, 5142–5145 (2010).
Schreirer, B., Stumpp, C., Wiesner, S. & Höcker, B. Proc. Natl Acad. Sci. USA 106, 18491–18496 (2009).
Metz, S. et al. Proc. Natl Acad. Sci. USA 108, 8194–8199 (2011).
Jeffrey, P. D. et al. Proc. Natl Acad. Sci. USA 90, 10310–10314 (1993).
Korndörfer, I. P., Schlehuber, S. & Skerra, A. J. Mol. Biol. 330, 385–396 (2003).
Fowler, D. M. et al. Nature Meth. 7, 741–746 (2010).
Koide, S. & Sidhu, S. S. ACS Chem. Biol. 4, 325–334 (2009).
Koga, N. et al. Nature 491, 222–227 (2012).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ghirlanda, G. A recipe for ligand-binding proteins. Nature 501, 177–178 (2013). https://doi.org/10.1038/nature12463
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature12463