Computational biology and bioinformatics

Definition

Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods used include analytical methods, mathematical modelling and simulation.

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Latest Research and Reviews

  • Research |

    Sohrab Shah, David Huntsman and colleagues report the genomic analysis of 133 ovarian cancers spanning different subtypes. They identify seven subgroups using point mutation and structural variation signatures and use these genomic features to stratify ovarian cancers both between and within histotypes.

    • Yi Kan Wang
    • , Ali Bashashati
    • , Michael S Anglesio
    • , Dawn R Cochrane
    • , Diljot S Grewal
    • , Gavin Ha
    • , Andrew McPherson
    • , Hugo M Horlings
    • , Janine Senz
    • , Leah M Prentice
    • , Anthony N Karnezis
    • , Daniel Lai
    • , Mohamed R Aniba
    • , Allen W Zhang
    • , Karey Shumansky
    • , Celia Siu
    • , Adrian Wan
    • , Melissa K McConechy
    • , Hector Li-Chang
    • , Alicia Tone
    • , Diane Provencher
    • , Manon de Ladurantaye
    • , Hubert Fleury
    • , Aikou Okamoto
    • , Satoshi Yanagida
    • , Nozomu Yanaihara
    • , Misato Saito
    • , Andrew J Mungall
    • , Richard Moore
    • , Marco A Marra
    • , C Blake Gilks
    • , Anne-Marie Mes-Masson
    • , Jessica N McAlpine
    • , Samuel Aparicio
    • , David G Huntsman
    •  & Sohrab P Shah
  • Research |

    A high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the physical interactions among peripheral mononuclear leukocytes revealed known immunomodulators and also approved drugs as regulators of unexpected targets, including MST1R.

    • Gregory I Vladimer
    • , Berend Snijder
    • , Nikolaus Krall
    • , Johannes W Bigenzahn
    • , Kilian V M Huber
    • , Charles-Hugues Lardeau
    • , Kumar Sanjiv
    • , Anna Ringler
    • , Ulrika Warpman Berglund
    • , Monika Sabler
    • , Oscar Lopez de la Fuente
    • , Paul Knöbl
    • , Stefan Kubicek
    • , Thomas Helleday
    • , Ulrich Jäger
    •  & Giulio Superti-Furga

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