Computational biology and bioinformatics

Definition

Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods used include analytical methods, mathematical modelling and simulation.

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Latest Research and Reviews

  • Reviews |

    Glucose-responsive insulin is a therapeutic that modulates its potency, concentration or dosing relative to a patient’s dynamic glucose concentration. This Perspective summarizes some of the recent accomplishments in this field as well as discussing new computational algorithms that may aid in the development of such therapeutics.

    • Naveed A. Bakh
    • , Abel B. Cortinas
    • , Michael A. Weiss
    • , Robert S. Langer
    • , Daniel G. Anderson
    • , Zhen Gu
    • , Sanjoy Dutta
    •  & Michael S. Strano
    Nature Chemistry 9, 937–943
  • Research | | open

    Proteins fold under mechanical force during co-translational folding at the ribosome. Here, the authors use single molecule magnetic tweezers to study the influence of chaperones on protein folding and show that the ribosomal chaperone trigger factor acts as a mechanical foldase by promoting protein folding under force.

    • Shubhasis Haldar
    • , Rafael Tapia-Rojo
    • , Edward C. Eckels
    • , Jessica Valle-Orero
    •  & Julio M. Fernandez
  • Research | | open

    The RNA Recognition Motif (RRM) is the most ubiquitous RNA binding domain. Here the authors combined NMR and molecular dynamics simulations and show that the RRM RNA binding surface exists in different states and that a conformational switch of aromatic side-chains fine-tunes sequence specific binding affinities.

    • Nana Diarra dit Konté
    • , Miroslav Krepl
    • , Fred F. Damberger
    • , Nina Ripin
    • , Olivier Duss
    • , Jiří Šponer
    •  & Frédéric H.-T. Allain
  • Research | | open

    Active locomotion requires closed-loop sensorimotor co ordination between perception and action. Here the authors show using behavioural, imaging and modelling approaches that gaze orientation during phototaxis behaviour in larval zebrafish is related to oscillatory dynamics of a neuronal population in the hindbrain.

    • Sébastien Wolf
    • , Alexis M. Dubreuil
    • , Tommaso Bertoni
    • , Urs Lucas Böhm
    • , Volker Bormuth
    • , Raphaël Candelier
    • , Sophia Karpenko
    • , David G. C. Hildebrand
    • , Isaac H. Bianco
    • , Rémi Monasson
    •  & Georges Debrégeas

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