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Isoxazolyl Penicillins and Penicillinase

Nature volume 195, pages 1300–1301 (1962)Cite this article

Abstract

THE isoxazolyl series of penicillinase-resistant penicillins has been described by Doyle et al.1. Many members of this series are acid-stable, and considerably more active against staphylococci than methi-cillin. Three members of this series (BRL.1400 5-methyl-3-phenyl-4-isoxazolylpenicillin, BRL. 1577 5-methyl-3-p-chlorphenyl-4-isoxazolylpenicillin and BRL.1621 5-methyl-3-o-chlorphenyl-4-isoxazolylpenicillin) have been investigated for antibacterial activity and for stability to, induction of, affinity for, and inhibitory action on, the penicillinases of Staph. aureus and B. cereus.

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Authors and Affiliations

  1. Department of Bacteriology, Guy's Hospital Medical School, London Bridge, London, S.E.1

    J. T. SMITH, J. M. T. HAMILTON-MILLER & R. KNOX

Authors
  1. J. T. SMITH
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  2. J. M. T. HAMILTON-MILLER
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  3. R. KNOX
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SMITH, J., HAMILTON-MILLER, J. & KNOX, R. Isoxazolyl Penicillins and Penicillinase. Nature 195, 1300–1301 (1962). https://doi.org/10.1038/1951300a0

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