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An analysis of more than 500 sites distributed worldwide finds that declines in the abundance of terrestrial insects are attributable mainly to decreases in species that were formerly abundant, rather than being the result of losses of rare species.
Mitochondria have a pivotal role in the transport of dietary lipids in enterocytes, a finding that might have relevance to understanding the aberrant gastrointestinal function in patients with mitochondrial disorders.
Messenger RNAs transcribed from olfactory-receptor genes may have non-coding functions that include recruitment of transcriptional enhancers and inhibition of potentially thousands of competing alleles to ensure stable transcription of a single allele.
Neural population activity in the medial entorhinal cortex of mice can be organized into ultraslow oscillatory sequences, with periods extending up to the minute range.
We report the experimental realization and room-temperature operation of a low-power (20 pW) moiré synaptic transistor based on an asymmetric bilayer graphene/hexagonal boron nitride moiré heterostructure.
A global profile of tropical cyclone population exposure for the period 2002–2019 shows a steady increase, with approximately 560 million people exposed yearly and a disproportionate exposure among those with lower socioeconomic status.
A study reports cryogenic electron microscopy structures of the respiratory syncytial virus polymerase bound to its genomic and antigenomic viral RNA promoters.
In zebrafish embryos, active complexes of Wnt5b and its membrane-bound receptor Ror2 are transported between cells via cellular protrusions called cytonemes to initiate paracrine Wnt5b signalling in cells that do not endogenously express the receptor.
Digital measurements of proximity and duration of exposure by the NHS COVID-19 app show a strong relation to actual infections among 7 million contacts notified in England and Wales, with longer durations translating to increased risk of transmission.
Genome-wide replication timing maps of mouse embryos from the zygote to the blastocyst stage were generated using single-cell Repli-seq, shedding light on the establishment of the epigenome at the beginning of mammalian development.
Coscientist is an artificial intelligence system driven by GPT-4 that autonomously designs, plans and performs experiments by incorporating large language models empowered by tools such as internet and documentation search, code execution and experimental automation.
Structural studies show how the PfRCR complex of Plasmodium falciparum forms a bridge between erythrocyte and parasite membranes, and how PfCyRPA-binding antibodies neutralize invasion through a steric mechanism, opening the way to new approaches in rational vaccine design.
Atomic electron tomography is used to determine the 3D atomic positions and chemical species of medium- and high-entropy alloy nanoparticles and quantitatively characterize the local lattice distortion, strain tensor, twin boundaries, dislocation cores and chemical short-range order.
Polariton-enhanced Purcell effects can be used to reduce the triplet density in blue phosphorescent organic light-emitting diodes, thereby extending their operational lifetimes by decreasing the annihilation of high-energy, long-lived blue triplets.
Cryo-electron microscopy structures of the PP2A:B55 holoenzyme bound to its inhibitors ARPP19 and FAM122A show distinct binding modes of the two inhibitors.
A stream of young neurons migrating into the entorhinal cortex (EC) continues postnatally in humans, but not in macaques; these young neurons, which belong to a unique class of local circuit cells, continue to be recruited in the EC during infancy and early childhood.
An explainable deep learning model using a chemical substructure-based approach for the exploration of chemical compound libraries identified structural classes of compounds with antibiotic activity and low toxicity.
Enzyme-bound ketyl radicals derived from thiamine diphosphate are selectively generated through single-electron oxidation by a photoexcited organic dye and shown to lead to enantioselective radical acylation reactions.
Phospholipids enhance the structural and colloidal integrity of hybrid organic–inorganic lead halide perovskites and lead-free metal halide nanocrystals, which then exhibit enhanced robustness and optical properties.
