Perspectives

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  • Quantifying molecular complexity has the potential to enhance retrosynthetic analysis and, thus, aid the development of efficient total syntheses. This Perspective discusses methods for rigorous, reproducible complexity measurement, highlighting their potential to revolutionize traditional complex molecule synthesis and uncover new synthetic opportunities.

    • Brandon A. Wright
    • Richmond Sarpong
    Perspective
  • The assessment of the aromaticity of actinide compounds has proven a controversial task. This Perspective highlights the application of state-of-the-art computational tools in assessing the aromaticity of actinide complexes and clusters and explains why commonly used magnetic probes, not just the nucleus-independent chemical shift but also the magnetically induced ring current, might be insufficient for assessing the aromaticity of these species.

    • Zahra Badri
    • Cina Foroutan-Nejad
    Perspective
  • The four core effects of high-entropy alloys are discussed and greater insights are presented. These clarifications are helpful in understanding materials from low entropy (simple two-component or three-component alloys) to high entropy (five components or greater), and in general materials design.

    • Wei-Lin Hsu
    • Che-Wei Tsai
    • Jien-Wei Yeh
    Perspective
  • Mechanochemistry is the science of inducing a chemical reaction through the application of mechanical force. This Perspective focuses on combining traditional mechanochemistry with different energy inputs — heat, light, sound or electrical impulses — to advance mechanochemical synthesis.

    • Valentina Martinez
    • Tomislav Stolar
    • Krunoslav Užarević
    Perspective
  • Endergonic photocatalysis enables the catalytic and atom-economic synthesis of products with higher free energies than reactants. This Perspective highlights current progress in endergonic photocatalysis by summarizing the energetics of these reactions and points out the industrial potential of such processes.

    • Huaiju Wang
    • Ya-Ming Tian
    • Burkhard König
    Perspective
  • Studies employing machine-learning (ML) tools in the chemical sciences often report their evaluations in a heterogeneous way. The evaluation guidelines provided in this Perspective should enable more rigorous ML reporting.

    • Andreas Bender
    • Nadine Schneider
    • Tiago Rodrigues
    Perspective
  • In this Perspective, a vision of a fully reconfigurable microfluidic device that can change its shape and function dynamically is outlined. Reconfigurable microfluidic platforms can enable new functionalities, which have the potential to go beyond the reach of current lab-on-a-chip systems.

    • Federico Paratore
    • Vesna Bacheva
    • Govind V. Kaigala
    Perspective
  • We propose that life originated in spontaneously formed catalytic lipid micelles. Accumulating experimental evidence shows that such micelles undergo compositional autocatalytic reproduction. Lipid-first constitutes a parsimonious alternative to the RNA-first scenario.

    • Amit Kahana
    • Doron Lancet
    Perspective
  • Reversible addition–fragmentation chain-transfer (RAFT) polymerization and atom transfer radical polymerization (ATRP) are evaluated in terms of their mechanistic strengths and weaknesses, versatility and latest synthetic advances.

    • Nghia P. Truong
    • Glen R. Jones
    • Athina Anastasaki
    Perspective
  • Although a stalwart in materials science, electron diffraction has only recently become popular for characterizing molecular structures. This Perspective describes practical aspects of the method, which affords complementary information to X-ray and neutron diffraction.

    • Tim Gruene
    • Julian J. Holstein
    • Bernhard Keppler
    Perspective
  • Implementing effective chemomechanical coupling in the microscopic world is challenging. This Perspective describes recent advances of chemically-powered swimming or diffusion of objects on the molecular scale, nanoscale and microscale.

    • Yifei Zhang
    • Henry Hess
    Perspective
  • Understanding the relationship between reaction rate and thermodynamic driving force is central to developing efficient catalysts. This Perspective describes this relationship and the conditions that can give rise to reversible catalysis, which is relevant to energy conversions of fuels and motor proteins alike.

    • Vincent Fourmond
    • Nicolas Plumeré
    • Christophe Léger
    Perspective
  • Theoretical models of clusters that account for molecular symmetry offer guidelines for their design. This Perspective describes the models and how we can synthesize the clusters thus designed.

    • Takamasa Tsukamoto
    • Tetsuya Kambe
    • Kimihisa Yamamoto
    Perspective
  • Bimetallic complexes are fertile territory for investigating metal–metal cooperativity. This Perspective highlights how complexes with two proximal metals have tunable features of relevance to bond activation, catalysis and unprecedented reactivity.

    • Jesús Campos
    Perspective
  • This Perspective discusses the prospects of assembling multiple molecular machines within ordered frameworks, with the goal of producing artificial molecular factories in which molecular motions are coupled, synchronized and amplified across multiple length scales, leading to robust and stimuli-responsive solids.

    • Simon Krause
    • Ben L. Feringa
    Perspective
  • Molecular design and synthesis, from small molecules to supramolecular assemblies, combined with new spectroscopic probes of quantum coherence and theoretical modelling, offer a broad range of possibilities to realize practical quantum information science applications in computing, communications and sensing.

    • Michael R. Wasielewski
    • Malcolm D. E. Forbes
    • K. Birgitta Whaley
    Perspective