Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Cells with mitochondrial defects are shown to be eliminated by cell competition in the early mouse embryo, thus suggesting that cell competition acts as a purifying selection that optimizes mitochondrial performance during development.
Wiese et al. find that oxaloacetate generated through increased activation of PKM2 can inhibit lactate dehydrogenase A, shedding light on the long observed PKM2 paradox during Warburg metabolism in cancer cells.
Using budding yeast and human endothelial cells, Li et al. find that increased synthesis of acetyl-CoA in the nucleus promotes histone acetylation at subtelomeric regions, thus leading to telomere silencing defects and cellular senescence.
Wigger, Barovic and Brunner et al. perform a multidimensional analysis of islets from metabolically characterized patients who had undergone pancreatectomy, observing remarkable heterogeneity between samples from individuals with type 2 diabetes, thus arguing against models of linear beta-cell dedifferentiation in diabetes.
Through integration of lipidomic and proteomic analyses of exosomes from patients with COVID-19, Lam et al. find that exosomes from different stages of infection have distinct compositions and can evoke distinct responses in recipient cells.
Using patient-derived colorectal cancer tumour enteroids, Schwartz et al. find that ectopic expression of hepcidin in the tumour epithelium establishes an axis to sequester iron to maintain the nucleotide pool and sustain proliferation.
Laurila et al. extend findings from rodents to humans by demonstrating, in a clinical trial, that the gut hormone secretin, which is secreted in response to a meal, induces thermogenesis and satiation in healthy males.
Boyd and LoCoco et al. link ω-6 polyunsaturated fatty acid–rich diet to development of peripheral nerve damage in mice, revealing diet as a risk factor for chronic pain.
Zhang et al. show that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype via itaconate metabolism.
Longitudinal changes in the serum metabolome and transcriptional changes in immune cells are mapped in children from two different ethnic groups in West Africa who were exposed to seasonal malaria, thereby identifying an immunosuppressive role of endogenous steroids that are induced by P. falciparum infection.
Simpson and colleagues systematically interrogate the influence of dietary carbohydrate type and quality on the obesogenic impact of protein-diluted diets in mice.
Little is known regarding the specificity and functional organization of peripheral clocks in mammals. Manella et al. find that the liver-clock is responsible for buffering the effects of nutrient challenges on the rhythmicity of other peripheral tissues.
Plasma proteomic profiles from 650 adult humans are measured before and after a 20-week exercise regimen to determine proteins associated with baseline cardiorespiratory fitness and improvements in response to exercise.
Fiorina and colleagues document alterations in glucose metabolism in patients with COVID-19 and use continuous glucose monitoring to show that glycaemic abnormalities could still be detected 2 months after disease onset in patients who had recovered.
Wu, Harrison and colleagues visualize lactate production at subcellular resolution in migrating endothelial cells and identify hotspots of glycolytic activity, mediated by RhoA and the glucose transporter SLC2A3, that couple cellular energy metabolism with cytoskeleton remodelling and cell motility.
Bile acids are shown to enter the brain and regulate short-term reductions in food intake after a meal by inhibiting neuropeptide release from agouti-related peptide/neuropeptide Y neurons.
A high-throughput chemical screen identifies the salt-inducible kinase inhibitor HG-9-91-01 as a driver of β cell proliferation, acting through an ATF6-dependent unfolded protein response.
Timblin et al. demonstrate that LPS or hydroxyoestrogen-induced mitochondrial stress triggers mitohormesis in macrophages, restraining inflammatory gene activation by suppressing oxidative metabolism.