Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Using budding yeast and human endothelial cells, Li et al. find that increased synthesis of acetyl-CoA in the nucleus promotes histone acetylation at subtelomeric regions, thus leading to telomere silencing defects and cellular senescence.
Wigger, Barovic and Brunner et al. perform a multidimensional analysis of islets from metabolically characterized patients who had undergone pancreatectomy, observing remarkable heterogeneity between samples from individuals with type 2 diabetes, thus arguing against models of linear beta-cell dedifferentiation in diabetes.
Using patient-derived colorectal cancer tumour enteroids, Schwartz et al. find that ectopic expression of hepcidin in the tumour epithelium establishes an axis to sequester iron to maintain the nucleotide pool and sustain proliferation.
Laurila et al. extend findings from rodents to humans by demonstrating, in a clinical trial, that the gut hormone secretin, which is secreted in response to a meal, induces thermogenesis and satiation in healthy males.
Zhang et al. show that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype via itaconate metabolism.
Longitudinal changes in the serum metabolome and transcriptional changes in immune cells are mapped in children from two different ethnic groups in West Africa who were exposed to seasonal malaria, thereby identifying an immunosuppressive role of endogenous steroids that are induced by P. falciparum infection.
Simpson and colleagues systematically interrogate the influence of dietary carbohydrate type and quality on the obesogenic impact of protein-diluted diets in mice.
Little is known regarding the specificity and functional organization of peripheral clocks in mammals. Manella et al. find that the liver-clock is responsible for buffering the effects of nutrient challenges on the rhythmicity of other peripheral tissues.
Plasma proteomic profiles from 650 adult humans are measured before and after a 20-week exercise regimen to determine proteins associated with baseline cardiorespiratory fitness and improvements in response to exercise.
Fiorina and colleagues document alterations in glucose metabolism in patients with COVID-19 and use continuous glucose monitoring to show that glycaemic abnormalities could still be detected 2 months after disease onset in patients who had recovered.
Wu, Harrison and colleagues visualize lactate production at subcellular resolution in migrating endothelial cells and identify hotspots of glycolytic activity, mediated by RhoA and the glucose transporter SLC2A3, that couple cellular energy metabolism with cytoskeleton remodelling and cell motility.
A high-throughput chemical screen identifies the salt-inducible kinase inhibitor HG-9-91-01 as a driver of β cell proliferation, acting through an ATF6-dependent unfolded protein response.
Timblin et al. demonstrate that LPS or hydroxyoestrogen-induced mitochondrial stress triggers mitohormesis in macrophages, restraining inflammatory gene activation by suppressing oxidative metabolism.
Cancer metabolism adapts the metabolic network of its cell of origin. Mahendralingam et al. find that lineage-rooted metabolic identities of normal mammary cells reflect breast cancer subtype metabolism.
UCP1 is exclusively expressed in brown and beige adipocytes, where it drives thermogenesis through futile substrate cycling. Mills et al. identify a endocrine pathway mediated by the UCP1 catabolic circuit that antagonizes liver inflammation by lowering the concentration of succinate in the liver extracellular fluid.
Using a CRISPR genetic screen for solute transporters and a metabolic compound library screen, Li et al. identify purine transport and de novo synthesis as key regulators of BRD4, a histone acetylation reader.
Irx3 and Irx5 are effectors of the FTO locus, which is associated with obesity. Son et al. show regulation of hypothalamic neurogenesis by Irx3 and Irx5, uncovering a role for these genes in leptin response and energy homeostasis.
Teijeiro et al. find that IL-17A pathogenically reprograms adipocytes and that pharmacological targeting of IL-17A production with digoxin protects mice from diet-induced obesity.