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Applying machine learning to an objective framework for suicidality, the authors demonstrate that four suicidal thought and behavior variables can be predicted with high accuracy and may present a scalable system for suicide risk assessment.
In this study, the authors investigate the association between price inflation and mental health service uptake in the United Kingdom, demonstrating that increasing costs of living exacerbate mental health needs, particularly among adults and older populations.
In this prospective longitudinal study of alcohol consumption and patterns in heavy drinking young adults, significant reductions in alcohol use quantity, frequency and problems were observed from pre- to post-pandemic onset.
Analyzing national registry data, the authors use within-sibling design and two-sample Mendelian randomization to identify bidirectional causal relationships between educational attainment (EA) and mental health conditions, demonstrating that lower levels of EA were differentially associated with some disorders, such as major depressive disorder, but that attention-deficit/hyperactivity disorder causally affected EA.
Wade and colleagues analyze data from the Bucharest Early Intervention Project to examine whether stress reactivity measured at age 12 may serve as a mechanism linking early institutional deprivation with psychopathology at age 16.
The authors examined the effect of psychosocial therapy, in addition to medication for heroin dependence, on inhibitory control brain activity and behavioral performance in individuals with heroin use disorder.
In this pilot study, the authors detected specific brain regions that can be precisely targeted with transcranial magnetic stimulation to influence heart rate. The heart–brain coupling might serve as a readout to identify optimal individualized transcranial magnetic stimulation targets for depression.
The authors report data from the emergency department AURORA study to characterize resilience in more detail than the absence of psychopathology after trauma.
This study identifies a set of risk factors that fully mediate and uniquely contribute to the relationship between sex assigned at birth and posttraumatic stress disorder severity.
Using stereotactic electroencephalography, the authors identified differential amygdala activation in response to emotional faces in participants with treatment-resistant depression compared with non-depressed participants with epilepsy, suggesting possible deep brain stimulation targets.
In this cross-species translational study, the authors look at the longitudinal consequences of stress during adolescent development on HPA function and postpartum behaviors in mice and in humans and suggest that glucocorticoid receptor antagonists may serve as a potential treatment for postpartum depression.
In this article, the authors demonstrate that haloperidol D2/D3 dopamine antagonism contributes to flexibility in beliefs about the intentions of social partners during a sharing game.
Singh and colleagues present an integrative genotypic approach using large-scale GWAS data for depression and coronary artery disease to identify genes associated with both conditions.
A study on a large cohort of military veterans of European and African ancestries finds no evidence that the APOE ε4 genotype moderates the impact of combat exposure on posttraumatic stress disorder symptom severity and diagnostic status.
Using a longitudinal structural imaging design, the authors assessed cortical anatomy and genes linked to methylphenidate activity to identify treatment-associated responses in adults with attention deficit hyperactivity disorder.
Using a large sample from the UK Biobank, the authors investigate the effects of dietary patterns on multiple aspects of brain health and mental health.
The authors examine the longitudinal relationship between residential greenness and the incidence of depression and anxiety using a sample of 409,556 participants from the UK Biobank.
Zhao, Liu et al. investigate the relationship between cognitive decline, chronic musculoskeletal pain and brain structure using an algorithm that can detect deviations from normative brain aging.
Chen et al. employed ecological momentary assessment in two different sample populations from the United States and China to develop proxy measures for emotion regulation flexibility.