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Lee et al. identify a positive relationship between life stress and current psychological symptoms in individuals with low, but not high, cortisol response and positive affectivity.
In this prospective cohort study of Syrian refugee children living in Lebanon, authors identified that daily exposure to stressors was the factor most strongly associated with children’s mental health problems.
Using magnetic resonance imaging and connectome-based predictive modelling, Gao et al. find that brain connectivity data can predict suicide risk in patients with late-life depression.
Traynor, Ruocco et al. find that the conjoint magnetic seizure therapy and dialectical behaviour therapy lead to a rapid, significant and clinically meaningful reduction in suicidal ideation in individuals with comorbid borderline personality disorder and treatment-resistant depression.
Man, Gao and colleagues find that methylphenidate treatment in children with attention deficit hyperactivity disorder is associated with reduced risk of physical abuse.
In this network and pairwise meta-analysis of 498 brain imaging studies, McCutcheon et al. demonstrate patterns of distinct and overlapping brain volume changes across psychiatric disorders.
Osimo et al. developed two models to predict the risk of treatment-resistant schizophrenia in patients with a first-episode psychosis using blood-based biomarkers and sociodemographic data routinely collected at psychosis onset in psychosis early intervention services in the United Kingdom. They used clozapine treatment as a proxy for treatment-resistant schizophrenia using data from 785 patients for model development and 1,110 patients for external validation.