Series on Cancer Therapy

Check out our Series of Review articles on emerging concepts in cancer therapy, novel therapeutic approaches and the challenges in translating preclinical work to the clinic. 

Announcements

  • Emerging therapeutic approaches in cancer image

    Register for our free webinar focusing on emerging therapeutic approaches in cancer, with Drs Haidong Dong, Adrian Harris, Jan-Paul Medema, Yi-Long Wu and our Chief Editor Alexia-Ileana Zaromytidou discussing the latest developments and ongoing challenges in cancer therapy | Thursday 24th June, 8-9.30 am (EDT), 2-3.30 pm (CET), 8-9.30 pm (CST)

  • Connected Network picture by Alamy, cover for the Cancer Milestone on "The AI revolution in Cancer"

    View our webinar on "The AI Revolution in Cancer", exploring recent advances on digital histopathology and Artificial Intelligence to predict molecular features and patient prognosis pan-cancer, with Dr. Jakob N. Kather (Aachen University) and Dr. Moritz Gerstung (EMBL-EBI), with a follow-up Q&A session moderated by Dr. Miguel Foronda (Nature Cancer). Free registration.

Nature Cancer is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

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    • Immuno-oncology approaches have shown little efficacy against high-grade glioma, a devastating manifestation of brain cancer. A new study now finds a metabolic vulnerability in IDH1-mutant glioma that can be targeted to reprogram tumor-infiltrating macrophages and create a tumor microenvironment that is more responsive to immune-checkpoint therapy.

      • Marie Jo Halaby
      • Tracy L. McGaha
      News & Views
    • Institutional clinical data repositories provide a depth and consistency of data elements that is difficult to match even with data pooled from diverse sources. A study now demonstrates how real-world data and clinical encounters can be captured in an integrated ‘data story’ to enable continuous learning and hypothesis generation in oncology.

      • Joseph O. Deasy
      • Peter D. Stetson
      News & Views
    • Prostate cancer is largely unresponsive to immunotherapy. A new study finds elevated expression of the chemokine IL-8, or its mouse homolog Cxcl15, in prostate cancer after castration, which leads to the recruitment of immunosuppressive myeloid cells. Blocking tumor infiltration with these cells could improve the response to immune-checkpoint inhibition and androgen-deprivation therapy.

      • Ravi A. Madan
      • Claudia Palena
      News & Views
    • Despite substantial advances in understanding of the molecular features of gliomas, the therapeutic options for these aggressive tumors remain scarce. Rich, Mitchell and colleagues provide their views about a phase 1 clinical trial testing the safety and efficacy of vaccines against cancer expressing mutant metabolic enzyme IDH1 in patients with high-grade glioma.

      • Sameer Agnihotri
      • Kailin Yang
      • Jeremy N. Rich
      Cancer in Translation
  • The Biden administration has proposed a new agency to drive innovation in health research, including cancer. The focus on cancer and accelerated development is welcome, but for the time being, whether and how these plans will materialize is less clear.

    Editorial
  • Social media have emerged as a key communication tool for scientists. Here we explore how to reap the benefits and avoid the pitfalls of social networking.

    Editorial
  • The treatment of triple-negative breast cancer remains chemotherapy based and lacks targeted drugs. However, immunotherapy combinations have shown promising activity, targeted chemotherapy options via antibody–drug conjugates are in the clinic, and molecular means of identifying targetable subsets are on the horizon. This Clinical Outlook discusses current and future possibilities for treating triple-negative breast cancer.

    • Lisa A. Carey
    Clinical Outlook
  • Making data available is essential for validating and furthering scientific discoveries. Helping authors navigate whether, how and in what form to share the data is also essential.

    Editorial
  • The COVID-19 pandemic is proving a major setback for achieving gender equality. Post-pandemic recovery efforts must focus on supporting diversity and bridging the gender gap.

    Editorial
Clinical Cancer Genomics

Clinical Cancer Genomics

Advances in sequencing and genomic technologies are rapidly expanding our understanding of cancer and in turn the role of genomics in clinical oncology.
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