A CRISPR dropout screen for tRNA regulators identified YRDC as the top essential gene in glioblastoma stem cells. Threonine acts as a substrate of YRDC to facilitate the N6-threonylcarbamoyladenosine (t6A) tRNA modification and shift translation toward mitosis-related genes with a codon bias. Our findings support targeting glioblastoma growth by a well-tolerated dietary therapy.
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References
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This is a summary of: Wu, X. et al. Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming. Nat. Cancer https://doi.org/10.1038/s43018-024-00748-7 (2024).
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Threonine fuels brain tumor growth through a conserved tRNA modification. Nat Cancer (2024). https://doi.org/10.1038/s43018-024-00750-z
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DOI: https://doi.org/10.1038/s43018-024-00750-z
