Volume 2 Issue 7, July 2018
Ultrasound-enabled targeting of specific brain circuits
This issue highlights neuroengineering advances, including optogenetic control of the activity of opposing muscle pairs, silicon interfaces for light-controlled non-genetic neuromodulation, genome editing in the brain of a mouse model of fragile X syndrome, and the generation of neural tissues via the modulation of culture conditions and of induced neuronal cells via direct reprogramming of fibroblasts.
The cover illustrates the non-invasive modulation of brain circuits, with cell-type and spatiotemporal specificity, via focused ultrasound and virally encoded receptors engineered to be activated by a designer drug.
Image: Maayan Harel and Jerzy Szablowski. Cover Design: Alex Wing.
