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Volume 2 Issue 6, June 2018

The promise of cell therapies

This issue includes a Focus on cell therapies, with an emphasis on cardiac regenerative medicine and immunotherapy. Also highlighted in this issue are a replenishable epicardial device for the sustained delivery of therapeutics, the mechanical in vivo maturation of human intestinal organoids, a cell-culture method for the formation of organ-specific metastases, and a microvasculature-on-a-chip device.

The cover illustrates the delivery of a cell therapeutic to diseased tissue.

Image: cancer cells, David McCarthy / Science Photo Library; needle, Steve Gschmeissner / Science Photo Library. Cover Design: Alex Wing.

Volume 2 Issue 6

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Editorial

  • For cell therapies to transition from promises to products, increased efforts need to be put into the identification of the factors and biological mechanisms that affect safety and efficacy, and into the design of cost-effective methods for the harvesting, expansion, manipulation and purification of the cells.

    Editorial

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Comment & Opinion

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News & Views

  • A physiologically relevant microvasculature-on-a-chip device enables the study of microvascular pathology associated with inflammation and haematological diseases.

    • Jessica Motherwell
    • Walter Lee Murfee
    News & Views

  • Heart tissue with an adult-like phenotype can be obtained by electromechanically conditioning, with increasing intensity, early-stage human induced pluripotent stem cells derived from cardiomyocytes.

    • Wahiba Dhahri
    • Rocco Romagnuolo
    • Michael A. Laflamme
    News & Views
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Reviews

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Research

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Focus

  • For cell therapies to transition from promises to products, increased efforts need to be put into the identification of the factors that affect safety and efficacy, and into cell manufacturing.

    Focus
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