News & Comment

  • News & Views |

    The combination of ultrafast ultrasound and positron emission tomography–computed tomography enables the simultaneous 3D imaging of anatomy and metabolism at high resolution.

    • Mark Dewhirst
  • Editorial |

    The communication of research findings, in both written and oral forms, would benefit from concepts used in cinematographic storytelling.

  • News & Views |

    Synthetic mammalian cells engineered to synthesize a painkiller in response to volatile spearmint reduce chronic pain in mice and do not seem to elicit adverse effects.

    • Daniel D. Lewis
    •  & Cheemeng Tan
  • News & Views |

    Nanoparticles carrying an antibiotic and bearing a peptide that targets the bacterium Staphylococcus aureus effectively suppress staphylococcal infections in mice.

    • Li-Li Li
    •  & Hao Wang
  • News & Views |

    Single-cell traction-force measurements performed on fluorescently labelled elastomeric surfaces can probe the physiological and pathological behaviour of thousands of cells in a single experiment.

    • Agnes M. Resto-Irizarry
    •  & Jianping Fu
  • Editorial |

    The translational achievements, commercialization prospects and eventual clinical and societal impacts of biomedical work accrue over a long time. They should be better captured and publicized.

  • News & Views |

    Commensal microbes engineered to convert natural compounds found in cruciferous vegetables into molecules with anticancer properties prevent carcinogenesis and cause the regression of colorectal cancer in mice fed with a vegetable diet.

    • David A. Drew
    •  & Andrew T. Chan
  • News & Views |

    Occluders for the left atrial appendage that are patient-specific, thus ensuring better fitting and potentially less complications, can be made by 3D-printing inflatable polymer devices on the basis of data derived from computed tomography scans.

    • Carola Gianni
    •  & Andrea Natale
  • News & Views |

    Grafting platelet-derived nanovesicles onto the surface of cardiosphere-derived cardiac stem cells enables the cells to better engraft in infarcted tissue following systemic injection in rats and pigs.

    • Philippe Menasché
  • News & Views |

    Rare-earth-doped nanoprobes emitting short-wavelength infrared light enable the detection of metastatic lesions in multiple organs.

    • Miqin Zhang
  • News & Views |

    A method inspired by cryptography maps neural activity to limb movement without requiring the simultaneous collection of neural activity in the motor cortex and of the corresponding physical actions.

    • Vikash Gilja
  • News & Views |

    A humanized mouse model of X-linked severe combined immunodeficiency suggests that the safety of correcting the human IL2RG gene in haematopoietic stem cells depends on both gene-correction frequency and the conditioning regimen used before cell transplantation.

    • Shengdar Q. Tsai
  • Editorial |

    Advances in microscopy and the application of machine learning to histology will modernize the examination of tissues in the clinical laboratory and in the operating room.

  • News & Views |

    Optical imaging of fluorescently labelled tissue illuminated by ultraviolet light does not require microscope slides and makes for a rapid alternative to conventional histology.

    • Daniel A. Orringer
    •  & Sandra Camelo-Piragua
  • News & Views |

    Prolonged local delivery, via an injectable hydrogel, of a miRNA known to induce cardiomyocyte proliferation stimulates the recovery of mice from myocardial infarction.

    • Katie A. Mitzelfelt
    •  & Charles E. Murry
  • News & Views |

    The expression of two DNA repair factors improves the recombination of single-stranded oligodeoxynucleotides with Cas9-induced double-strand breaks, facilitating precise and efficient gene editing.

    • Sanum Bashir
    •  & Ralf Kühn
  • News & Views |

    The DNA mutation that causes Duchenne muscular dystrophy in mice can be corrected, with minimal off-target effects, by gold nanoparticles carrying the CRISPR components.

    • Zachary Glass
    • , Yamin Li
    •  & Qiaobing Xu
  • News & Views |

    The early stages of the formation of calcific nodules in the aortic valve can be detected by two-photon excited fluorescence microscopy.

    • Jack P. M. Andrews
    •  & Marc R. Dweck
  • News & Views |

    A theoretical model of chromatin packing heterogeneity predicts patterns in gene expression and can be used to screen for effective chemotherapeutic adjuvants.

    • Alexandra Zidovska
  • News & Views |

    The genetic, epigenetic and transcriptomic profiles of human induced pluripotent stem cells are shaped by the reprogramming route.

    • Thomas F. Allison
    •  & William E. Lowry
  • News & Views |

    Light-sheet microscopy reveals 3D tumour heterogeneity in optically cleared paraffin-embedded tumour samples.

    • Boyan K. Garvalov
    •  & Ali Ertürk
  • News & Views |

    Flexible piezoelectric sensors can detect mechanical deformations in the gastrointestinal tract of ambulating pigs and simultaneously harvest energy from it.

    • Ghazaleh Haghiashtiani
    •  & Michael C. McAlpine
  • News & Views |

    High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases.

    • Tobias Langenberg
    • , Joost Schymkowitz
    •  & Frederic Rousseau
  • Editorial |

    When reading or writing about biomedical findings, be mindful of factual accuracy and wary of unapparent caveats.