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A collagen-binding interleukin-12 formulation intravenously injected into mice bearing established immunologically cold mouse tumours led to marked tumour remission, particularly when combined with checkpoint-inhibitor immunotherapy.
The world needs mass at-home serological testing for antibodies elicited by SARS-CoV-2, and rapid and frequent point-of-care testing for the presence of the virus’ RNA in selected populations.
This Review summarizes progress in the development of engineering strategies employed in reproductive science and medicine, with a focus on biomaterials and microfluidic approaches.
A ‘smart’ toilet that uses pressure and motion sensors, biometric identification, urinalysis strips, a computer-vision uroflowmeter and machine learning longitudinally tracks biomarkers of health and disease in the user’s urine and stool.
A retrievable, porous and anti-fibrotic macrodevice for the encapsulation of cells provides long-term protection to human cells expressing therapeutic proteins after device implantation in the intraperitoneal space of immunocompetent mice.
Intravenously injected functionalized carbon quantum dots that bind to the large neutral amino acid transporter 1 and that structurally mimic large amino acids selectively accumulate in human tumours in mice, facilitating targeted theranostics.
This Perspective outlines the current map and known functions of populations of tumour-infiltrating myeloid cells in cancer, and discusses their implications for cancer therapy and biological research.
The conversion of a deuterated substrate into cellular metabolites in vivo can be quantified via decreases in the proton nuclear magnetic resonance signals of these metabolites.
The European Union’s new regulatory framework for medical devices has central implications for the development of new devices, particularly by start-ups.
The photothermal and magnetothermal properties of carbon-coated iron cobalt nanoparticles with a polymer shell make them sensitive tracers for in vivo magnetic particle imaging, magnetic resonance imaging and photoacoustic imaging.
An optical-imaging instrument that integrates multispectral imaging for the detection of fluorescence in the first and second near-infrared windows aids the surgical resection of liver tumours in patients.
The detection of small tumours with positron emission tomography is significantly enhanced by 64Cu-labelled polycationic polymers sensitive to the acidic pH of tumours.
Epithelial cancers of the upper intestinal tract in animals, in biopsied human tissue and in a human patient can be detected via a fluorescently labelled inhibitor of the DNA-repair enzyme poly(ADP-ribose) polymerase 1.
Progress in fluorescence-guided systems and contrast agents for real-time intraoperative assistance during tumour-resection operations should benefit patient outcomes.
Nanoscale strains in the intact whole joints of young, old and osteoarthritic mice can be resolved ex vivo via synchrotron X-ray tomography when combined with nanometrically precise mechanical loading.
A fluorescently labelled inhibitor of the DNA repair enzyme poly(ADP–ribose) polymerase 1 is used to detect epithelial cancers of the upper intestinal tract in animals, in biopsied human tissue and in a human patient.
High-resolution raster-scanning optoacoustic mesoscopy provides detailed morphological and physiological insights into the responses of tumours to vascular-targeted therapies.
A cyclic octapeptide labelled with a near-infrared dye and that binds, with high affinity at high levels of calcium, to phosphorylated protein Annexin A2 in a range of solid tumours, serves as a tumour-selective imaging probe.