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In tendon cells under shear stress, the induction of an influx of calcium by the mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking, which increases tendon stiffness and potentially improves jumping performance.
The restoration of a local chemokine gradient by nanoparticles non-covalently anchored on the surface of systemically administered red blood cells delays cancer progression in mouse models of lung metastasis.
An analysis of the neural coding of speech sounds in anaesthetized gerbils shows that sound-processing algorithms used by hearing aids can degrade the wearer’s ability to discriminate sounds.
The dynamics of multiregional brain networks in response to temporally varying patterns of ongoing direct electrical stimulation can be predicted by modelling, with variabilities in prediction accuracy explained by at-rest functional connectivity.
The time course of tumour responses to immunotherapies can be mathematically predicted on the basis of tumour-growth rates, the rates of immune activation and of tumour–immune-cell interactions, and the efficacy of immune-mediated tumour killing.
A prototype device for performing magnetic-resonance-imaging scans of the brain that integrates a lightweight permanent magnet and low-power gradient coils is suitable for eventual use at the bedside.
Epileptic foci in mice can be better visualized with magnetic resonance imaging by using an intravenously administered nanoparticle that crosses the blood–brain barrier and is sensitive to the abnormal electrical activity of foci.
The sustained expression of RNA-targeting Cas9 delivered intramuscularly or systemically by adeno-associated viral vectors eliminates pathogenic foci of expanded-repeat transcripts and reverses muscle-disease phenotypes in mouse models of myotonic dystrophy type 1.
Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.
By using CRISPR and transposon constructs, pigs have been genetically modified to inactivate endogenous retroviruses and to enhance the compatibility of their organs with the human immune and coagulation systems.
The DNA methylation of the promoter region of the oncogenic Yes-associated protein is reversibly regulated by the stiffness of the extracellular matrix.
The capacity of mesenchymal stromal cells to promote vascular regeneration in vivo can be enhanced by the combination of specific small-molecule inhibitors and the right waveform of mechanical stretch.
A minimally invasive microneedle patch detects specific protein biomarkers in dermal interstitial fluid at high sensitivity via a needle-integrated immunoassay coupled with an ultrabright fluorescent label.
Data from consumer smartwatches can improve the detection of COVID-19 when combined with symptom self-reporting, and can also detect the disease in pre-symptomatic individuals.
Systemically injected lipid–polymer nanoparticles delivering small interfering RNAs into bone-marrow endothelium modulate leukocyte trafficking from the bone marrow to the blood.
Systemic viral delivery of a gene encoding for a light-sensitive red-shifted ion channel enables non-invasive neuronal stimulation deep in the brain of rodents.
Wearable piezoelectric thin films integrated with multiphysics modelling and three-dimensional digital image correlation can decode facial expressions in real time.
