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The enhanced accumulation and residence time of systemically administered interleukin-4 fused to serum albumin in lymph nodes and in the spleen prevents the development of multiple sclerosis in mice.
Systemically injected lipid–polymer nanoparticles encapsulating small interfering RNA for silencing genes in bone-marrow endothelial cells of mice improved the healing of the mice after myocardial infarction.
Optical contrast agents using AND-gate logic enhance the specificity and sensitivity of fluorescence-guided imaging in the resection of tumours and in the detection of metastases in mouse models of cancer.
A microfluidic assay that quantifies cell migration and proliferation can prospectively categorize patients with glioblastoma according to progression-free survival.
An intravenously administered electric-field-sensitive contrast agent for magnetic resonance imaging that crosses the blood–brain barrier improves lesion visualization with high sensitivity and target-to-background ratio in mice.
Pigs can be genetically modified to inactivate endogenous retroviruses and to display enhanced compatibility with the human immune system using a combination of CRISPR–Cas9 and transposon technologies.
Customized soft electrode arrays that are well adjusted to specific anatomical environments, functions and experimental models can be rapidly prototyped via the robotically controlled deposition of conductive inks and insulating inks.
A multiplexed fluorescence-based assay detects seroconversion in individuals infected with SARS-CoV-2 from less than 1 µl of blood as early as the day of the first positive nasopharyngeal nucleic acid test after symptom onset.
A one-pot enzymatic assay for the fluorescence detection of RNA accurately and rapidly detects specific viral and bacterial pathogens, as shown for SARS-CoV-2 RNA in clinical samples.
Molecular and physiological phenotypes in mouse models of myotonic dystrophy type I can be sustainably reversed by CRISPR-mediated targeting of toxic RNA repeats.
A gelling hypotonic solution for ocular delivery that forms a uniform and clear thin layer conformal to the ocular surface resists clearance from blinking and extends the residence time of the delivered drugs.
Soft multilayer electronic arrays on endocardial balloon catheters allow for multiplexed high-density spatiotemporal sensing and actuation, as shown in perfused ex vivo hearts.
The specific high-sensitivity enzymatic reporter unlocking (SHERLOCK) assay detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA with high sensitivity and specificity in hundreds of nasopharyngeal and throat swab samples collected at Siriraj Hospital in Thailand.
The burst release of annexin A5 from intravenously injected nanoparticles that rapidly degrade in tumours generates robust anti-tumour immunity by shifting late-stage immunosuppressive apoptosis to immunostimulatory necrosis.
Intratumoural injection of a self-assembling supramolecular hydrogel that slowly releases a STING agonist and a chemotherapeutic agent reduces tumour immunosuppression and increases antitumour responses in mice.
Analyses of data from intracortical brain–computer interfaces implanted in rhesus macaques and in a human suggest that the circuit design parameters of current recording interfaces can be relaxed considerably without loss of performance.
An antibody-discovery pipeline integrating single-cell mRNA-sequence analysis, bioinformatics, synthetic biology and high-throughput functional analyses enables the rapid discovery of potent human monoclonal antibodies against viral pathogens.
Post-mortem histopathological data can be used to classify neuropathologies into six transdiagnostic clusters, and patient membership to these clusters can be predicted from cognitive scores, genotype and protein levels in cerebrospinal fluid.