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A first-in-man study of robotic-assisted intraocular surgery shows the feasibility and safety of the robotic device for the peeling of retinal membranes and for the injection of a therapeutic under the retina.
An epicardial device that enables sustained and repeated administration of small molecules, macromolecules and cells directly to the epicardium provides therapeutic benefits in a rat model of myocardial infarction.
Uniaxial strain provided by compressed nitinol springs incorporated in human intestinal organoids transplanted into the mouse mesentery enhances organoid growth and maturation, and improves the similarity of the organoids to native human intestine.
β-Cyclodextrin nanoparticles carrying an antagonist of the toll-like receptors TLR7 and TLR8 drive the M1 phenotype in tumour-associated macrophages and improve immunotherapy response rates in tumour mouse models when used with checkpoint blockade.
A flexible magnetic resonance imaging coil bearing an array of high-impedance detectors can be stitched onto a glove and used to image the biomechanics of the hand’s soft tissue.
Polymer–lipid micelles with an ultralow undetectable critical micelle concentration make ultrastable drug carriers that significantly enhance therapeutic outcomes in a mouse model of melanoma.
The modification of protein and peptide therapeutics with tannic acid improves their ability to specifically target heart tissue, as shown with a rat model of myocardial ischaemia-reperfusion injury.
Intracellular, intercellular and extracellular silicon interfaces enable light-controlled non-genetic modulation of intracellular calcium dynamics, of cellular excitability, of neurotransmitter release from brain slices, and of brain activity in vivo.
A cell-culture method involving decellularized tissue scaffolds enables the spontaneous formation of cell colonies that phenotypically recapitulate in vivo organ-specific cancer metastases.
An endothelialized microfluidic system that recapitulates physiological properties of the microvasculature enables the real-time visualization of vascular-pathology features associated with sickle-cell disease and malaria, with high spatiotemporal resolution.
A hydrogel patch for the sustained delivery of extracellular vesicles from cardiomyocytes derived from induced pluripotent stem cells improves tissue regeneration in infarcted rat hearts.
A nanoparticle-based immunotherapy targeted to a protein responsible for signalling between monocytes and macrophages reduces plaque inflammation in atherosclerotic mice and appears to be safe in non-human primates.
Topically applied imaging nanoprobes for the detection of intracellular mRNA expression from connective tissue growth factor enable the detection of hypertrophic scars and keloids in the skin of small live animals and in ex vivo human skin.
A method that uses thin sheets of X-ray radiation to generate emissions of Cherenkov luminescence can image an oxygen-sensitive molecular probe to map oxygenation in tumours in vivo at submillimetre resolution and nanomolar sensitivity.
A continuous-acquisition method for reducing artefacts caused by the beating heart and other body motions in cardiovascular magnetic resonance imaging reduces the reliance on electrocardiography triggering and breath holds.
Culturing conditions affect the transcriptomic profiles of induced neuronal cells, and 3D co-cultures of induced neuronal cells and astrocytic cells can be rapidly generated from the same pool of human embryonic stem cells.
Self-assembled ribonucleoprotein octamers bearing an endosomolytic peptide and a siRNA–targeting-ligand conjugate facilitate endosomal destabilization and targeted delivery, achieving efficient gene silencing in mouse models of prostate cancer.
The characterization of protein–protein interactions by combined single-molecule pull-down and single-molecule co-immunoprecipitation assays uncovers, for specific cancers, their dependence on signalling complexes of the human epidermal growth-factor receptor.
Combining immune checkpoint inhibition with radiotherapy–radiodynamic therapy, enabled by intratumorally injected nanoscale metal–organic frameworks, promotes systemic antitumour immunity and tumour rejection in mouse models of breast and colorectal cancer.
A microfluidic assay that identifies sepsis from a single droplet of diluted blood by measuring the spontaneous motility of neutrophils showed 97% sensitivity and 98% specificity in two independent patient cohorts.