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Volume 1 Issue 1, January 2021

Aging in unity

The cover image of Nature Aging’s first issue illustrates the notion that aging concerns everyone, pointing to the need for social unity and joined research endeavors to solve issues and seize opportunities associated with human aging. Our first issue features research and opinion articles authored by biologists, clinicians, social scientists and civil society and industry leaders that reflect the breadth of our interests, from the intricate details of the core biology of aging to public health and societal questions associated with population aging.

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Image: Smartboy10 / DigitalVisionVectors / Getty. Cover design: Lauren Heslop.


  • We are excited to launch Nature Aging, a journal whose mission is to publish some of the most important and timely research from across the entire aging research spectrum and be a nexus for the diverse communities working on aging.



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Comment & Opinion

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News & Views

  • An extensive multiomic resource using human monocytes reveals large-scale remodeling of DNA methylation landscapes in healthy aging and accelerated or pathological aging contexts. This work provides an invaluable resource with important implications for the study of age-related changes in immune function.

    • Minhoo Kim
    • Bérénice A. Benayoun
    News & Views
  • The human gut microbiota is comprised of a vast assortment of trillions of microbial cells belonging to hundreds of different species, differing substantially between individual hosts. A new study has systematically investigated the relationship of host age to gut microbes in a geographically restricted and ethnically homogeneous human cohort, revealing key differences across ages and sexes.

    • Ezgi Özkurt
    • Falk Hildebrand
    News & Views
  • Chambers et al. show that senescent skin cells in older adults provoke monocyte-dependent local inflammation in response to injury, which hampers T cell recall responses to viruses. Importantly, they further show that this phenomenon can be blocked pharmacologically to boost adaptive immunity.

    • Herbert Kasler
    • Eric Verdin
    News & Views
  • Accurate blood tests for Alzheimer’s disease (AD) are critical tools that have the potential to revolutionize dementia research, clinical trials and clinical care. Models combining blood-based biomarkers that represent multiple aspects of AD brain pathology with key individual level factors may improve prediction of AD dementia.

    • Suzanne E. Schindler
    • Randall J. Bateman
    News & Views
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  • In this Perspective, Rando and Wyss-Coray discuss recent advances in the field of the biology of aging, focusing on new concepts related to the processes of cell and tissue aging and how they impact the healthspan and lifespan of an individual.

    • Thomas A. Rando
    • Tony Wyss-Coray
  • Intermittent and periodic fasting are emerging as important interventions with the potential to extend longevity and healthspan. This Review discusses how they affect longevity and healthspan in model organisms and humans, their connection to major nutrient-sensing signaling pathways and the importance of refeeding.

    • Valter D. Longo
    • Maira Di Tano
    • Novella Guidi
    Review Article
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