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This study identifies a new germline-to-soma aging signal tuned by mating in Caenorhabditiselegans. The authors find that germline piRNAs influence longevity and somatic maintenance by transcriptionally regulating germline-to-soma Hedgehog signaling.
Xie et al. identify activation of the innate immune cGAS-STING pathway in human Alzheimer’s disease (AD) brain and 5×FAD mouse model of AD. Suppressing the cGAS-STING pathway is shown as a target to alleviate AD-associated pathogenesis in mice.
Kabir et al. show that aged bone marrow induces smooth muscle cell (SMC) polyclonality in atherosclerosis. Decreased TET2 levels in aged myeloid cells lead to silenced integrin β3, resulting in increased TNFα signaling and the expansion of multiple SMC progenitors.