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Age-friendly cities initiatives aim to facilitate active and healthy aging. Focusing on the urban physical environment, the authors argue that longevity-ready cities that aim for better health and well-being for people of all ages from a life-course perspective can accomplish more than initiatives focused solely on old age.
The integrated stress response governs adaptive reprogramming of protein synthesis following external or internal signals. The authors discuss its role in aging and longevity, and highlight strategies to enhance health and resilience.
This Perspective discusses the socioeconomic concept of the longevity dividend, in which healthy and productive aging is achieved through a positive correlation between three dimensions: life expectancy, health and the economy.
In this Perspective, McMahon et al. examine the emerging roles and implications of post-transcriptional RNA modifications, or the epitranscriptome, in aging and age-related diseases, highlighting potential epitranscriptomic mechanisms and/or their dysfunction that may regulate the aging process.
Despite scarce evidence, ageism is often cited as a social factor contributing to elder mistreatment. This Perspective examines the limited research linking these issues and proposes a model and research agenda to further understand the relationship.
Linda Fried and colleagues argue that physical frailty reflects the dysregulation of a complex dynamical system underpinning health and resilience, and discuss the implications for new prevention and treatment approaches.
In this Perspective, Rando and Wyss-Coray discuss recent advances in the field of the biology of aging, focusing on new concepts related to the processes of cell and tissue aging and how they impact the healthspan and lifespan of an individual.
