Volume 23 Issue 6, June 2018

Volume 23 Issue 6

Neural cells derived from EBV-immortalized B-lymphocytes from patients with bipolar disorder (BD). The figure shows representative examples of cells from BD patients who are Lithium responsive (LR, left panels), Lithium non-responsive (NR, middle panels) and neurotypical controls (right panels). Neural progenitors cells (NPC, top 3 panels) express Nestin (green) and Sox2 (red). Neurons (bottom 3 panels) express the pan neuronal marker MAP2 (red) and the hippocampus dentate gyrus (DG) granular cell marker, Prox1 (Prox1-GFP reporter in green). Neurons from BD patients are hyperexcitable and the patient's response to Lithium can be predicted by intrinsic electrophysiological properties. Scale bar: 50 μm. Please refer to the article by Stern et al. on pages 1453–1465.


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