Molecular Targets For Therapy (MTT)

Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation

• R R Rosato
• Y Dai
• S Grant

The synthetic peptide PFWT disrupts AF4–AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells

• R S Srinivasan
• J B Nesbit
• C S Hemenway

Efficacy of dual-specific Bcr-Abl and Src-family kinase inhibitors in cells sensitive and resistant to imatinib mesylate

• A J Tipping
• S Baluch
• J V Melo

Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro

• Y Satou
• K Nosaka
• M Matsuoka

The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells

• D M Lucas
• M E Davis
• M R Grever

Topoisomerase IIα expression in mantle cell lymphoma: a marker of cell proliferation and a prognostic factor for clinical outcome

• C Schrader
• P Meusers
• M Tiemann

The conjugate Rituximab/saporin-S6 completely inhibits clonogenic growth of CD20-expressing cells and produces a synergistic toxic effect with Fludarabine

• L Polito
• A Bolognesi
• F Stirpe

Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics

• J Roche
• C Zeng
• H A Drabkin

Identification of a gene element essential for leukemia-specific expression of transgenes

• N Hosen
• M Yanagihara
• H Sugiyama

Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias

• S Zhao
• M Konopleva
• M Andreeff

A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl

• S Mishra
• B Zhang
• N Heisterkamp

Telomerase is limiting the growth of acute myeloid leukemia cells

• A Röth
• S Vercauteren
• P M Lansdorp

Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia

• P Dvorak
• D Dvorakova
• J Mayer

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

• X-Y Pei
• Y Dai
• S Grant

Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1α

• Y Huang
• K-M Du
• G-Q Chen

Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia

• B Z Carter
• M Milella
• M Andreeff

Effects of the farnesyl transferase inhibitor R115777 on normal and leukemic hematopoiesis

• J L Liesveld
• J E Lancet
• J D Rosenblatt

Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

• P Lunghi
• A Tabilio
• A Bonati

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

• A M Martelli
• P L Tazzari
• L Cocco

Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation

• J G Shelton
• P W Moye
• J A McCubrey