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Volume 101 Issue 11, November 2021

The cover shows the histological relationship between osteoclasts and blood vessels in normal and arthritic rats. For more information, see the paper by Kukita et al, this issue, p 1449.

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Technical Report

  • This study describes the characterization of a human endometrial epithelial cell line, hEM3. hEM3 is not transformed, can grow organoids, and does not harbor pathogenic mutations in genes involving DNA mismatch repair (MMR). hEM3 with ARID1A knockout has been generated for drug screening in an ARID1A-deficient and MMR-proficient context. In conclusion, hEM3 can be a model for studying endometrial pathogenesis.

    • Youngran Park
    • Jin-Gyoung Jung
    • Tian-Li Wang
    Technical Report
  • The authors describe quantitatively and qualitatively different forms of experimental autoimmune encephalitis (EAE) in cynomolgus macaques. They found that bacterial contaminants within recombinant human myelin oligodendrocyte glycoprotein seemed to aggravate disease evolution. They provide anatomopathological features of fulminant and progressive forms of EAE, allowing them to distinguish specific factors influencing the evolution of this model of autoimmune demyelinating disease.

    • Lev Stimmer
    • Joachim Confais
    • Ché Serguera
    Technical Report
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