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Potential mechanisms contributing to the effects of angiotensin receptor–neprilysin inhibitors (ARNIs) on 24-h blood pressure and hypertensive heart disease. CV, cardiovascular; LV, left ventricular.
27 million Japanese are hypertensive disease and 89.6% of them are treated with any anti-hypertensive medications. This is the first study utilizing the National Database of Health Insurance Claims and Specific Health Checkups to determine the number and age-adjusted prevalence of hypertensive patients and treated hypertensive patients in Japan.
The impact of intrauterine hypoxia on acetylcholine (ACh)-mediated endothelium dependent vasodilatation in fetal sheep middle cerebral artery (MCA). Intrauterine hypoxia decreased CHRM3 expression, and inhibited NOS3 bioactivities due to ROS over-production and ERK1/2 inhibition, leading to MCA dysfunction.