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An unbiased primary sensory neuron screen identifies the chemotherapeutic agent bortezomib as a potent TRPV1 sensitizer. Such long-term sensitization could lead to axonal death and sensory loss, a major symptom of bortezomib-induced neuropathy.
This article presents a hitherto unknown role of a-Synuclein protein to function as a Pickering agent for TDP-43-RNA biomolecular condensates to emulsify them towards heterotypic amyloid fibrils.
Carbon/nitrogen stoichiometry of ectomycorrhizas varies with the fungal symbiont and determines the plant carbon and nitrogen resource allocation to species-rich ectomycorrhizal communities.
Heart-specific overexpression of the RNA binding protein IGF2BP2 leads to dilated cardiomyopathy (DCM) and death in mice that can be rescued if downregulated in time, suggesting that IGF2BP2 could be a target for therapeutic intervention in DCM.
Analysis of ChIP-Seq of multiple histone modifications across shoots and roots in two nutrient supply conditions, coupled with machine learning, reveals new organ-specific patterns of epigenetic regulation in response to nitrate in tomatoes.
Delineation of the zone-specific dynamics of hepatocytes during pregnancy in mice demonstrates that midgestational periportal hepatocyte proliferation is critical for maternal glucose homeostasis during late pregnancy.
A chromosome-scale genome assembly for the grass, Orinuse kokonorica, combined with RNA-seq data provides insight into the evolutionary history of the species and the genomic basis for the divergence of two closely related grass genera.
This study identifies the WYL domain-containing regulator SiwR as activator of a DNA damage inducible operon. The findings underscore the role of WYL domains as signal-sensing switches in bacterial adaptation to changing environments and stress.
Behavioral tests together with specific neuronal recordings and manipulation suggest that aging-related decline in social and inanimate novelty seeking is caused by a reduction in the spontaneous firing of midbrain VTA/SNc dopaminergic neurons.
A global grassland study reveals soil moisture, not local treatments, drives microbial and detritivore activity, highlighting the potential influence of climate change and human interventions on grassland ecosystems.
Multi-domain and complex structure assembly through domain segmentation and single domain modeling algorithms method outperforms existing state-of-the-art approaches.
This study on the dynamics of the bacterial community in ant-built patches during the life cycle of arboreal ant colonies indicates that ecological processes driven by ant behavior and substrate changes shape the bacterial community.
Single-molecule fluorescence identifies how a G protein and constitutively activating mutations impact GPCR conformational equilibria by altering the population of a crucial intermediate state essential for activation.
A non-coding variant upstream of the CDC20 promoter leads to down-regulation of CDC20 expression and up-regulation of a more proliferative and melanocytic transcriptional program that may aid in accelerating tumor growth.
A multimodal study in comatose patients suggests that awakening was paradoxically more probable when EEG fluctuations were predictable and were integrated into a global recovery of every dimension (eye-opening behaviour, clocked control hormones).
The UBR4 UBR box can bind not only to type 1 N-degron, such as arginine, but also to amino acids with aromatic rings belonging to type 2 N-degrons, and this interaction occurs through pi-interactions.
The authors report excessive amounts of modification-mediated errors in Listeria strains during Nanopore sequencing that are due to novel modifications that were untrained in the Nanopore basecalling model. A whole-genome amplification and a reference-based computational methods (Modpolish) can correct these modification-mediated errors without the need for demodification.
A photodynamic therapy with polphylipoprotein (PLP) was conducted using both normal cells and cancer cells originating from the same sources. PLP enables highly effective cancer treatment by employing a unique mechanism of autophagy.
The authors describe a method for generating functional neural spheroids and assembloids for disease modeling and drug discovery by cell aggregation of differentiated human iPSC derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain.