Focus 20 November 2018

Novel therapeutic genes and gene silencing approaches for cancer treatment

As important as vector design is the selection of the therapeutic gene to deliver. He we highlight advances in gene selection for both expression and silencing strategies.

Content

Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling
- Y Zhu
- M Tao
- Y Xie
Original Article18 Mar 2016 Cancer Gene Therapy
RETRACTED ARTICLE: Blockage of miR-92a-3p with locked nucleic acid induces apoptosis and prevents cell proliferation in human acute megakaryoblastic leukemia
- M Sharifi
- R Salehi
Original Article11 Dec 2015 Cancer Gene Therapy
Gene therapy for ovarian cancer using carbonyl reductase 1 DNA with a polyamidoamine dendrimer in mouse models
- A Kobayashi
- Y Yokoyama
- H Mizunuma
Original Article20 Nov 2015 Cancer Gene Therapy
Examining the effect of gene reduction in miR-95 and enhanced radiosensitivity in non-small cell lung cancer
- W Ma
- C-n Ma
- Y-j Zhang
Original Article26 Feb 2016 Cancer Gene Therapy
Trastuzumab-targeted gene delivery to Her2-overexpressing breast cancer cells
- K Mann
- M Kullberg
Original ArticleOpen Access20 May 2016 Cancer Gene Therapy
Adenovirus vector carrying REIC/DKK-3 gene: neoadjuvant intraprostatic injection for high-risk localized prostate cancer undergoing radical prostatectomy
- H Kumon
- Y Ariyoshi
- Y Nasu
Original ArticleOpen Access21 Oct 2016 Cancer Gene Therapy
Breast cancer gene therapy using an adenovirus encoding human IL-2 under control of mammaglobin promoter/enhancer sequences
- S Chaurasiya
- P Hew
- M M Hitt
Original Article6 May 2016 Cancer Gene Therapy
IL-15/sIL-15Rα gene transfer suppresses Lewis lung cancer growth in the lungs, liver and kidneys
- H Sun
- D Liu
Original Article8 Jan 2016 Cancer Gene Therapy
Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer
- H Zhang
- X Zhou
- Y Xie
Original Article13 Nov 2015 Cancer Gene Therapy
SiO₂@antisense molecules covered by nepetalactone, extracted from Nepeta gloeocephala, inhibits ILK phosphorylation and downstream PKB/AKT signaling in HeLa cells
- M Dehghany Ashkezary
- F Aboee-Mehrizi
- P Moradi
Original Article16 Dec 2016 Cancer Gene Therapy
Gene therapy using plasmid DNA-encoded anti-HER2 antibody for cancers that overexpress HER2
- H Kim
- S N Danishmalik
- H J Hong
Original ArticleOpen Access16 Sep 2016 Cancer Gene Therapy
The inhibition of epidermal growth factor receptor signaling by hexagonal selenium nanoparticles modified by SiRNA
- L Kamrani Moghaddam
- S Ramezani Paschepari
- A Jebali
Original Article9 Sep 2016 Cancer Gene Therapy
Tumor radiosensitization by gene therapy against endoglin
- M Stimac
- U Kamensek
- G Sersa
Original Article20 May 2016 Cancer Gene Therapy
Adenovirus-delivered wwox inhibited lung cancer growth in vivo in a mouse model
- Y Zhou
- F Shou
- Q You
Original Article30 Oct 2015 Cancer Gene Therapy
Phase I/II clinical trial to assess safety and efficacy of intratumoral and subcutaneous injection of HVJ-E in castration-resistant prostate cancer patients
- K Fujita
- Y Nakai
- N Nonomura
Original ArticleOpen Access12 May 2017 Cancer Gene Therapy
Enhanced antitumor effect of combining TRAIL and MnSOD mediated by CEA-controlled oncolytic adenovirus in lung cancer
- R Zhang
- X Zhang
- Y Wang
Original Article15 Apr 2016 Cancer Gene Therapy
shRNA-mediated silencing of hTERT suppresses proliferation and promotes apoptosis in osteosarcoma cells
- P Chen
- W-L Gu
- D-Q Li
Original Article11 Aug 2017 Cancer Gene Therapy
Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors
- P Ambady
- Y J Wu
- E A Neuwelt
Original ArticleOpen Access28 Jul 2017 Cancer Gene Therapy
Precise and efficient siRNA design: a key point in competent gene silencing
- E Fakhr
- F Zare
- L Teimoori-Toolabi
Review18 Mar 2016 Cancer Gene Therapy

Novel therapeutic genes and gene silencing approaches for cancer treatment

Content

Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling

RETRACTED ARTICLE: Blockage of miR-92a-3p with locked nucleic acid induces apoptosis and prevents cell proliferation in human acute megakaryoblastic leukemia

Gene therapy for ovarian cancer using carbonyl reductase 1 DNA with a polyamidoamine dendrimer in mouse models

Examining the effect of gene reduction in miR-95 and enhanced radiosensitivity in non-small cell lung cancer

Trastuzumab-targeted gene delivery to Her2-overexpressing breast cancer cells

Adenovirus vector carrying REIC/DKK-3 gene: neoadjuvant intraprostatic injection for high-risk localized prostate cancer undergoing radical prostatectomy

Breast cancer gene therapy using an adenovirus encoding human IL-2 under control of mammaglobin promoter/enhancer sequences

IL-15/sIL-15Rα gene transfer suppresses Lewis lung cancer growth in the lungs, liver and kidneys

Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer

SiO₂@antisense molecules covered by nepetalactone, extracted from Nepeta gloeocephala, inhibits ILK phosphorylation and downstream PKB/AKT signaling in HeLa cells

Gene therapy using plasmid DNA-encoded anti-HER2 antibody for cancers that overexpress HER2

The inhibition of epidermal growth factor receptor signaling by hexagonal selenium nanoparticles modified by SiRNA

Tumor radiosensitization by gene therapy against endoglin

Adenovirus-delivered wwox inhibited lung cancer growth in vivo in a mouse model

Phase I/II clinical trial to assess safety and efficacy of intratumoral and subcutaneous injection of HVJ-E in castration-resistant prostate cancer patients

Enhanced antitumor effect of combining TRAIL and MnSOD mediated by CEA-controlled oncolytic adenovirus in lung cancer

shRNA-mediated silencing of hTERT suppresses proliferation and promotes apoptosis in osteosarcoma cells

Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors

Precise and efficient siRNA design: a key point in competent gene silencing

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