Focus
Focus on Aging
- Focus issue:
- December 2015 Volume 21, No 12
Aging is associated with functional impairments in cellular pathways controlling genomic stability, proteostasis and metabolism, and is a major risk factor for several of the most prevalent diseases. This series of Reviews and Perspectives highlights the recent data that point toward the specific molecular pathways that are perturbed during aging and discuss potential ways to manipulate these pathways to prevent or alleviate age-related diseases.
Editorial
Focus on Aging
Aging: toward avoiding the inevitable - p1373
doi:10.1038/nm.4009
Aging is receiving more attention as a risk factor for human disease. With the correct modeling of human heterogeneity and consideration of the environmental factors involved in the aging process, we may be able to delay the onset of human disease.
Abstract - | Full Text - Aging: toward avoiding the inevitable | PDF (134 KB) - Aging: toward avoiding the inevitable
Q&A
Focus on Aging
Translational strategies in aging and age-related disease - pp1395 - 1399
Mary Armanios, Rafael de Cabo, Joan Mannick, Linda Partridge, Jan van Deursen & Saul Villeda
doi:10.1038/nm.4004
Six leaders in aging research discuss how to translate their findings in the field.
Abstract - | Full Text - Translational strategies in aging and age-related disease | PDF (681 KB) - Translational strategies in aging and age-related disease
Perspectives
Focus on Aging
Can aging be 'drugged'? - pp1400 - 1405
Celine E Riera & Andrew Dillin
doi:10.1038/nm.4005
In this Perspective, the current approaches to drug aging, and how new approaches may be developed in the future are discussed.
Abstract - | Full Text - Can aging be 'drugged'? | PDF (537 KB) - Can aging be 'drugged'?
Focus on Aging
Proteostasis and aging - pp1406 - 1415
Susmita Kaushik & Ana Maria Cuervo
doi:10.1038/nm.4001
In this Perspective, the current approaches to drug aging, and how new approaches may be developed in the future are discussed.
Abstract - | Full Text - Proteostasis and aging | PDF (1,962 KB) - Proteostasis and aging
Reviews
Focus on Aging
The metabolic regulation of aging - pp1416 - 1423
Toren Finkel
doi:10.1038/nm.3998
Toren Finkel reviews how metabolism and aging are connected, and highlights pathways that could be pharmacologically targeted to combat aging and age-related disease.
Abstract - | Full Text - The metabolic regulation of aging | PDF (1,195 KB) - The metabolic regulation of aging
Focus on Aging
Cellular senescence in aging and age-related disease: from mechanisms to therapy - pp1424 - 1435
Bennett G Childs, Matej Durik, Darren J Baker & Jan M van Deursen
doi:10.1038/nm.4000
In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting these cells to counteract disease.
Abstract - | Full Text - Cellular senescence in aging and age-related disease: from mechanisms to therapy | PDF (2,268 KB) - Cellular senescence in aging and age-related disease: from mechanisms to therapy
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