Research in regenerative medicine is advancing toward the goal of repairing damaged tissue and organs. Nature Biotechnology and Nature Medicine present a collection of reviews, features and commentaries that explore our current mechanistic understanding of stem cells, and the emerging technologies that will bring regenerative medicine to the clinic.
- Editorials
- News
- News Features
- Correspondence
- Commentary
- Podcast
- Feature
- Patents
- Perspectives
- Reviews
Editorials
Advancing regenerative medicine
doi:10.1038/nm.3658
Nature Medicine 20, (2014)
Regenerative medicine may enable replacement of damaged or diseased tissues. But its clinical success will require deeper understanding of the basic biology of the stem cell niche and coordination between stem cell biologists and those in other fields.
News
Letter campaign sought to pressure FDA action on stem cell clinics
Elie Dolgin
doi:10.1038/nm0814-796
Nature Medicine 20, (2014)
News Features
Between disease and a dish
Ken Garber
doi:10.1038/nbt.2977
Nature Biotechnology 32, (2014)
Correspondence
An FDA perspective on preclinical development of cell-based regenerative medicine products
Alexander M Bailey, Michael Mendicino & Patrick Au
doi:10.1038/nbt.2971
Nature Biotechnology 32, (2014)
Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells
Peter W Andrews, Joy Cavanagro, Robert Deans, Ellen Feigel, Ed Horowitz, Armand Keating, Mahendra Rao, Marc Turner, Ian Wilmut & Shinya Yamanaka
doi:10.1038/nbt.2973
Nature Biotechnology 32, (2014)
Patents
The global intellectual property landscape of induced pluripotent stem cell technologies
MacKenna Roberts, Ivan B Wall, Ian Bingham, Dominic Icely, Brock Reeve, Kim Bure, Anna French & David A Brindley
doi:10.1038/nbt.2975
Nature Biotechnology 32, (2014)
Perspectives
Translational strategies and challenges in regenerative medicine
Stefanie Dimmeler, Sheng Ding, Thomas A Rando & Alan Trounson
doi:10.1038/nm.3627
Nature Medicine 20, (2014)
Our understanding of stem cell biology is increasing, but the translation of this knowledge into regenerative medicine therapies for aged or diseased tissues is proving challenging. In this Perspective, four experts in the field discuss strategies for overcoming the major hurdles facing the translational regenerative field.
Reviews
Overcoming immunological barriers in regenerative medicine
Johannes L Zakrzewski, Marcel R M van den Brink & Jeffrey A Hubbell
doi:10.1038/nbt.2960
Nature Biotechnology 32, (2014)
Strategies for inducing immunological tolerance to transplanted cells are an important component of regenerative therapies.
Preparing the ground for tissue regeneration: from mechanism to therapy
Stuart J Forbes & Nadia Rosenthal
doi:10.1038/nm.3653
Nature Medicine 20, (2014)
The regeneration of injured tissues by exogenous and endogenous stem cells relies on the local microenvironment being conducive to repair.
Clinical imaging in regenerative medicine
Anna V Naumova, Michel Modo, Anna Moore, Charles E Murry & Joseph A Frank
doi:10.1038/nbt.2993
Nature Biotechnology 32, (2014)
Clinical imaging is indispensable in cell therapy to monitor tissue repair and the fate of transplanted cells.
Emerging interactions between skin stem cells and their niches
Ya-Chieh Hsu, Lishi Li & Elaine Fuchs
doi:10.1038/nm.3643
Nature Medicine 20, (2014)
The multiple stem cell populations in the skin are a model for studying the interactions of stem cells and their microenvironment or niche.
Modulating the stem cell niche for tissue regeneration
Steven W Lane, David A Williams & Fiona M Watt
doi:10.1038/nbt.2978
Nature Biotechnology 32, (2014)
Manipulating the stem cell niche could provide new ways of coaxing stem cells to repair damaged tissues.
Stem cell aging: mechanisms, regulators and therapeutic opportunities
Juhyun Oh, Yang David Lee & Amy J Wagers
doi:10.1038/nm.3651
Nature Medicine 20, (2014)
The mechanisms leading to age-dependent decline in stem cell function and potential therapeutic avenues for reversal of these effects are discussed.
3D bioprinting of tissues and organs
Sean V Murphy & Anthony Atala
doi:10.1038/nbt.2958
Nature Biotechnology 32, (2014)
3D bioprinting of tissues and organs will find application in tissue engineering, research, drug discovery and toxicology.
Hematopoietic stem cell niche maintenance during homeostasis and regeneration
Avital Mendelson & Paul S Frenette
doi:10.1038/nm.3647
Nature Medicine 20, (2014)
The maintenance and proliferation of hematopoietic stem cells after injury is regulated by signals from the bone marrow stem cell niche.
Lung regeneration: mechanisms, applications and emerging stem cell populations
Darrell N Kotton & Edward E Morrisey
doi:10.1038/nm.3642
Nature Medicine 20, (2014)
The search for cells that can regenerate lung tissue has been fueled by the need for improved clinical therapies for treatment of lung injury or degenerative lung diseases. Emerging techniques are allowing the identification of putative stem and progenitor cells in the lung and the understanding of the molecular mechanisms regulating lung development and regeneration.
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