Focus on The immunology of HIV

Nature Immunology presents a series of specially commissioned articles that discuss the most recent progress in understanding the immune response to HIV and how this new insight can be harnessed for prophylactic vaccines and immunotherapies.



Focus on The immunology of HIV

A formidable challenge p545


Better understanding of HIV biology, virus-host interactions and mechanisms of an efficient immune response advance efforts for effective vaccines and immunotherapies.



Focus on The immunology of HIV

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape pp546 - 553

Viviana Simon, Nicolin Bloch & Nathaniel R Landau


HIV devotes a large portion of its coding capacity to counteracting the function of mammalian antiviral proteins. Landau and colleagues discuss the biology of mammalian restriction factors and the viral accessory proteins that counteract them.

Focus on The immunology of HIV

Innate immunity against HIV-1 infection pp554 - 562

Marcus Altfeld & Michael Gale Jr


Innate effector mechanisms contribute to the control of viremia and modulate the quality of the adaptive immune response to HIV-1. Altfeld and Gale discuss the concerted actions of PRR signaling, innate immune cells and innate-adaptive crosstalk that direct the outcome of HIV-1 infection.

Focus on The immunology of HIV

Success and failure of the cellular immune response against HIV-1 pp563 - 570

Stephen A Migueles & Mark Connors


Understanding the success and failure of the HIV-specific cellular immune response has implications for immunotherapies and vaccines for HIV-1. Migueles and Connors discuss the mechanisms that are most likely responsible for durable and potent immunologic control of HIV-1 by the cellular immune response.

Focus on The immunology of HIV

Antibody responses to envelope glycoproteins in HIV-1 infection pp571 - 576

Dennis R Burton & John R Mascola


Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups. Burton and Mascola discuss how recent insight into the structure and immunology of non-neutralizing, strain-specific and broadly neutralizing antibodies guide HIV-1 vaccine design and therapeutic strategies.

Focus on The immunology of HIV

The impact of host genetic variation on infection with HIV-1 pp577 - 583

Paul J McLaren & Mary Carrington


An effect of host genetic variation on susceptibility to HIV-1 was identified early in the pandemic. McLaren and Carrington discuss the extent to which additional polymorphisms influence HIV-1 disease progression and how analysis of data sets may discover novel gene variants that affect the outcome of HIV-1.



Focus on The immunology of HIV

HIV reservoirs as obstacles and opportunities for an HIV cure pp584 - 589

Tae-Wook Chun, Susan Moir & Anthony S Fauci


The persistence of HIV reservoirs remains a barrier to sustained virologic remission in HIV-infected individuals after antiretroviral therapy is discontinued. Fauci and colleagues discuss the therapeutic strategies aimed at eliminating or controlling the virus in the absence of ART.


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