Focus
Focus on The immunology of HIV
- Focus
- June 2015 Volume 16, No 6
Nature Immunology presents a series of specially commissioned articles that discuss the most recent progress in understanding the immune response to HIV and how this new insight can be harnessed for prophylactic vaccines and immunotherapies.
Editorial
Focus on The immunology of HIV
A formidable challenge - p545
doi:10.1038/ni.3179
Better understanding of HIV biology, virus-host interactions and mechanisms of an efficient immune response advance efforts for effective vaccines and immunotherapies.
Full Text - A formidable challenge | PDF (183 KB) - A formidable challenge
Reviews
Focus on The immunology of HIV
Intrinsic host restrictions to HIV-1 and mechanisms of viral escape - pp546 - 553
Viviana Simon, Nicolin Bloch & Nathaniel R Landau
doi:10.1038/ni.3156
HIV devotes a large portion of its coding capacity to counteracting the function of mammalian antiviral proteins. Landau and colleagues discuss the biology of mammalian restriction factors and the viral accessory proteins that counteract them.
Abstract - Intrinsic host restrictions to HIV-1 and mechanisms of viral escape | Full Text - Intrinsic host restrictions to HIV-1 and mechanisms of viral escape | PDF (3,584 KB) - Intrinsic host restrictions to HIV-1 and mechanisms of viral escape
Focus on The immunology of HIV
Innate immunity against HIV-1 infection - pp554 - 562
Marcus Altfeld & Michael Gale Jr
doi:10.1038/ni.3157
Innate effector mechanisms contribute to the control of viremia and modulate the quality of the adaptive immune response to HIV-1. Altfeld and Gale discuss the concerted actions of PRR signaling, innate immune cells and innate-adaptive crosstalk that direct the outcome of HIV-1 infection.
Abstract - Innate immunity against HIV-1 infection | Full Text - Innate immunity against HIV-1 infection | PDF (1,222 KB) - Innate immunity against HIV-1 infection
Focus on The immunology of HIV
Success and failure of the cellular immune response against HIV-1 - pp563 - 570
Stephen A Migueles & Mark Connors
doi:10.1038/ni.3161
Understanding the success and failure of the HIV-specific cellular immune response has implications for immunotherapies and vaccines for HIV-1. Migueles and Connors discuss the mechanisms that are most likely responsible for durable and potent immunologic control of HIV-1 by the cellular immune response.
Abstract - Success and failure of the cellular immune response against HIV-1 | Full Text - Success and failure of the cellular immune response against HIV-1 | PDF (1,270 KB) - Success and failure of the cellular immune response against HIV-1
Focus on The immunology of HIV
Antibody responses to envelope glycoproteins in HIV-1 infection - pp571 - 576
Dennis R Burton & John R Mascola
doi:10.1038/ni.3158
Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups. Burton and Mascola discuss how recent insight into the structure and immunology of non-neutralizing, strain-specific and broadly neutralizing antibodies guide HIV-1 vaccine design and therapeutic strategies.
Abstract - Antibody responses to envelope glycoproteins in HIV-1 infection | Full Text - Antibody responses to envelope glycoproteins in HIV-1 infection | PDF (893 KB) - Antibody responses to envelope glycoproteins in HIV-1 infection
Focus on The immunology of HIV
The impact of host genetic variation on infection with HIV-1 - pp577 - 583
Paul J McLaren & Mary Carrington
doi:10.1038/ni.3147
An effect of host genetic variation on susceptibility to HIV-1 was identified early in the pandemic. McLaren and Carrington discuss the extent to which additional polymorphisms influence HIV-1 disease progression and how analysis of data sets may discover novel gene variants that affect the outcome of HIV-1.
Abstract - The impact of host genetic variation on infection with HIV-1 | Full Text - The impact of host genetic variation on infection with HIV-1 | PDF (590 KB) - The impact of host genetic variation on infection with HIV-1
Perspective
Focus on The immunology of HIV
HIV reservoirs as obstacles and opportunities for an HIV cure - pp584 - 589
Tae-Wook Chun, Susan Moir & Anthony S Fauci
doi:10.1038/ni.3152
The persistence of HIV reservoirs remains a barrier to sustained virologic remission in HIV-infected individuals after antiretroviral therapy is discontinued. Fauci and colleagues discuss the therapeutic strategies aimed at eliminating or controlling the virus in the absence of ART.
Abstract - HIV reservoirs as obstacles and opportunities for an HIV cure | Full Text - HIV reservoirs as obstacles and opportunities for an HIV cure | PDF (520 KB) - HIV reservoirs as obstacles and opportunities for an HIV cure