Focus on Tolerance Breakdown

Lighting the way forward - p1

doi:10.1038/ni0110-1

Although recent progress has aided our understanding of the processes that prevent immune tolerance breakdown, this Focus issue illustrates how much remains unknown about susceptibility to and pathogenesis of autoimmune diseases.

Full Text - Lighting the way forward | PDF (135 KB) - Lighting the way forward

Focus on Tolerance Breakdown

Levees of immunological tolerance - pp3 - 6

Diane Mathis & Christophe Benoist

doi:10.1038/ni.1833

Abstract - Levees of immunological tolerance | Full Text - Levees of immunological tolerance | PDF (244 KB) - Levees of immunological tolerance

Focus on Tolerance Breakdown

Regulatory T cells exert checks and balances on self tolerance and autoimmunity - pp7 - 13

Kajsa Wing & Shimon Sakaguchi

doi:10.1038/ni.1818

Abstract - Regulatory T cells exert checks and balances on self tolerance and autoimmunity | Full Text - Regulatory T cells exert checks and balances on self tolerance and autoimmunity | PDF (463 KB) - Regulatory T cells exert checks and balances on self tolerance and autoimmunity

Focus on Tolerance Breakdown

Checkpoints in lymphocyte development and autoimmune disease - pp14 - 20

Harald von Boehmer & Fritz Melchers

doi:10.1038/ni.1794

Abstract - Checkpoints in lymphocyte development and autoimmune disease | Full Text - Checkpoints in lymphocyte development and autoimmune disease | PDF (892 KB) - Checkpoints in lymphocyte development and autoimmune disease

Focus on Tolerance Breakdown

Mechanisms maintaining peripheral tolerance - pp21 - 27

Daniel L Mueller

doi:10.1038/ni.1817

Abstract - Mechanisms maintaining peripheral tolerance | Full Text - Mechanisms maintaining peripheral tolerance | PDF (2,527 KB) - Mechanisms maintaining peripheral tolerance

Focus on Tolerance Breakdown

Influence of microbial environment on autoimmunity - pp28 - 35

Alexander V Chervonsky

doi:10.1038/ni.1801

Abstract - Influence of microbial environment on autoimmunity | Full Text - Influence of microbial environment on autoimmunity | PDF (407 KB) - Influence of microbial environment on autoimmunity

Focus on Tolerance Breakdown

Autoimmunity: increasing suspects in the CD4⁺ T cell lineup - pp36 - 40

Matthew T Palmer & Casey T Weaver

doi:10.1038/ni.1802

Abstract - Autoimmunity: increasing suspects in the CD4+ T cell lineup | Full Text - Autoimmunity: increasing suspects in the CD4+ T cell lineup | PDF (480 KB) - Autoimmunity: increasing suspects in the CD4+ T cell lineup

Focus on Tolerance Breakdown

Mixed results with modulation of T_H-17 cells in human autoimmune diseases - pp41 - 44

Lawrence Steinman

doi:10.1038/ni.1803

Abstract - Mixed results with modulation of TH-17 cells in human autoimmune diseases | Full Text - Mixed results with modulation of TH-17 cells in human autoimmune diseases | PDF (459 KB) - Mixed results with modulation of TH-17 cells in human autoimmune diseases

Focus on Tolerance Breakdown

Research Highlights - p45

doi:10.1038/ni0110-45

Full Text - Research Highlights | PDF (71 KB) - Research Highlights