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Microorganisms In Recent Drug Discovery
This Web Focus on Microorganisms in Recent Drug Discovery from The Journal of Antibiotics brings together various studies of microorganisms that have contributed to recent developments in drug discovery. From traditional studies of microorganisms as sources of therapeutic efficacy to new approaches that focus on biosynthesis or screening, the collection of articles provides a perspective on how studies of antibiotics and microorganisms have contributed to drug discovery, and puts forward ideas on how research directions might change in the future.
Antibiotics' Role In Today's Drug Discovery
Antibiotics in the clinical pipeline in 2011 FREE
Mark S Butler, Matthew A Cooper
J Antibiot 64:6 413-425; advance online publication, May 18, 2011; doi:10.1038/ja.2011.44
Studies of microorganisms - traditional models of investigation
Cyanobacteria: an emerging source for drug discovery FREE
Rahul Kunwar Singh, Shree Prakash Tiwari, Ashwani K Rai and Tribhuban M Mohapatra
J Antibiot 64:6 401-412; advance online publication, April 6, 2011; doi:10.1038/ja.2011.21
Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance FREE
In-Kyoung Lee and Bong-Sik Yun
J Antibiot 64:5 349-359; advance online publication, February 9, 2011; doi:10.1038/ja.2011.2
Transformation of Microbial Products through Enzymatic Reaction
Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907 FREE
Satoshi Ueda, Takashi Shibata, Katsuhiko Ito, Nobutaka Oohata, Michio Yamashita, Motohiro Hino, Masato Yamada, Yasuhiro Isogai, Seiji Hashimoto
J Antibiot 64:2 169-175; advance online publication, December 1, 2010; doi:10.1038/ja.2010.151
Improved Biosynthetic Engineering
Improved precursor-directed biosynthesis in E.coli via directed evolution FREE
Ho Young Lee, Colin J B Harvey, David E Cane, Chaitan Khosla
J Antibiot 64:1 59-64; advance online publication, November 17, 2010; doi:10.1038/ja.2010.129
Screening
A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium FREE
Kyota Kimura, Masato Iwatsuki, Takeshi Nagai, Atsuko Matsumoto, Yoko Takahashi, Kazuro Shiomi, Satoshi Ōmura, Akio Abe
J Antibiot 64:2 197-203 advance online publication, December 8, 2010; doi:10.1038/ja.2010.155
New targets - contributions from new studies on viruses and malarial activity
β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents FREE
Gianfranco De Pascale, Ishac Nazi, Paul H M Harrison and Gerard D Wright
J Antibiot 64:7 483-487; advance online publication, April 27, 2011; doi:10.1038/ja.2011.37
A novel class of geldanamycin derivatives as HCV replication inhibitors targeting on Hsp90: synthesis, structure-activity relationships and anti-HCV activity in GS4.3 replicon cells FREE
Guang-zhi Shan, Zong-gen Peng, Yu-huan Li, Dong Li, Yan-ping Li, Shuai Meng, Lin-yan Gao, Jian-dong Jiang, Zhuo-rong Li
J Antibiot 64:2 177-182; advance online publication, December 22, 2010; doi:10.1038/ja.2010.161
In vitro and in vivo antimalarial activity of puberulic acid and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410 FREE
Masato Iwatsuki, Shohei Takada, Mihoko Mori, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tsukashima, Kenichi Nonaka, Rokuro Masuma, Kazuhiko Otoguro, Kazuro Shiomi, Satoshi Ōmura
J Antibiot 64:2 183-188; advance online publication, November 10, 2010; doi:10.1038/ja.2010.124
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