Focus
ChR2: Anniversary Issue
- Focus issue:
- September 2015 Volume 18, No 9
Editorial
ChR2: Anniversary Issue
ChR2 coming of age- p1191
doi:10.1038/nn.4103
10 years ago, channelrhodopsin-2 was expressed in neurons and shown to control their activity. In this issue, we consider how the field has developed since these early optogenetic experiments.
Overview
ChR2: Anniversary Issue
Optogenetics and the future of neuroscience- pp1200 - 1201
Edward S Boyden
doi:10.1038/nn.4094
Abstract - | Full Text - Optogenetics and the future of neuroscience | PDF (499 KB) - Optogenetics and the future of neuroscience
Q&A
ChR2: Anniversary Issue
Optogenetics: 10 years after ChR2 in neurons—views from the community- pp1202 - 1212
Antoine Adamantidis, Silvia Arber, Jaideep S Bains, Ernst Bamberg, Antonello Bonci, György Buzsáki, Jessica A Cardin, Rui M Costa, Yang Dan, Yukiko Goda, Ann M Graybiel, Michael Häusser, Peter Hegemann, John R Huguenard, Thomas R Insel, Patricia H Janak, Daniel Johnston, Sheena A Josselyn, Christof Koch, Anatol C Kreitzer, Christian Lüscher, Robert C Malenka, Gero Miesenböck, Georg Nagel, Botond Roska, Mark J Schnitzer, Krishna V Shenoy, Ivan Soltesz, Scott M Sternson, Richard W Tsien, Roger Y Tsien, Gina G Turrigiano, Kay M Tye and Rachel I Wilson
doi:10.1038/nn.4106
On the anniversary of the Boyden et al. (2005) paper that introduced the use of channelrhodopsin in neurons, Nature Neuroscience asks selected members of the community to comment on the utility, impact and future of this important technique.
Full Text - Optogenetics: 10 years after ChR2 in neurons—views from the community | PDF (2,208 KB) - Optogenetics: 10 years after ChR2 in neurons—views from the community
Historical Commentary
ChR2: Anniversary Issue
Optogenetics: 10 years of microbial opsins in neuroscience- pp1213 - 1225
Karl Deisseroth
doi:10.1038/nn.4106
Over the past decade, modern optogenetics has emerged from the convergence of developments in microbial opsin engineering, genetic methods for targeting, and optical strategies for light delivery. In this Historical Commentary, Karl Deisseroth reflects on the optogenetic landscape, from the important steps but slow progress in the beginning to the acceleration in discovery seen in recent years.
Abstract - | Full Text - Optogenetics: 10 years of microbial opsins in neuroscience | PDF (3,952 KB) - Optogenetics: 10 years of microbial opsins in neuroscience