Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotropic glutamate receptor 5 on oligodendrocytes.

The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.

The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

Social status mediates individual differences in methamphetamine-seeking by modulating dopaminergic pathways. In subordinate rodents, the mesolimbic pathway is stronger, and the mesocortical pathway is weaker, whereas dominant rodents show the opposite pattern.

White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8⁺ T cell recruitment, myelinated axon damage and functional decline in aging mice.

How sensory signals from both sides of the body are integrated into a single percept is not well understood. Park et al. show that callosal signaling supports the integration of bilateral tactile stimuli in a state- and task-dependent manner.

Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotropic glutamate receptor 5 on oligodendrocytes.

The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.

Social status mediates individual differences in methamphetamine-seeking by modulating dopaminergic pathways. In subordinate rodents, the mesolimbic pathway is stronger, and the mesocortical pathway is weaker, whereas dominant rodents show the opposite pattern.

Neuron-specific DNA methylation and intragenic enhancers target the Rett syndrome protein methyl-CpG-binding protein 2 to regulate genes that delineate closely related neuron types, suggesting breakdown of fine-scale neuronal specification in developmental disorders.

Eleanor Maguire was a visionary cognitive neuroscientist whose research transformed our understanding of how the brain supports memory, navigation, and imagination.

Following the COVID-19 pandemic, a shift from traditional in-person conferences to virtual and hybrid formats was welcomed for its accessible, cost-effective approach to sharing scientific knowledge and connecting people. Here, we discuss an effective hybrid format that combines in-person and online elements to foster inclusivity by providing a flexible, cost-effective alternative to in-person meetings.