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Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment
Aging induces pathological changes in central nervous system (CNS) myelin, which in turn induce microglia dysregulation. What is the consequence of this microglial response on white matter pathology in aging? Groh et al. show that a maladaptive white matter-associated microglia state that emerges in aging recruits peripheral T cells to the CNS, which leads to degeneration of myelinated axons and loss of function.
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Pregnancy leads to long-lasting changes in human brain structure
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Neuroanatomical changes observed over the course of a human pregnancy
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Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration
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A dynamic and multimodal framework to define microglial states