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Geroprotectors are therapeutic interventions that aim to tackle the root causes of aging and thus help prevent age-related decline and age-related diseases. Examples of previously described geroprotectors include senolytic treatments (such as Quercetin and Dasatanib), VEGF, metformin and NMN. The editors of Nature Communications, Communications Medicine and Scientific Reports invite submissions on the preclinical development of geroprotectors, their preclinical testing, as well as their involvement in observational studies and clinical trials.