Mitochondrial function and metabolic health

Mitochondria are central hubs in a diversity of processes, including cellular energy metabolism, immunity, and signal transduction. Due to their function at the heart of cellular energy metabolism, the healthy functioning of our mitochondria is vitally important for overall metabolic health. As dynamic organelles, mitochondria can adapt to energetic, environmental, and other stressors, but also malfunction in a variety of ways. Evidence suggests that mitochondrial dysfunction may occur early in disease pathology, and has the potential to be modulated by genetics, environment, and lifestyle. Although a major factor in many disease states, an understanding of the precise involvement of mitochondria in the aetiology and prevention of metabolic disease will lead to further discoveries in this field.

This collection aims to cover a broad range of themes linking mitochondrial function to metabolic health and disease outcomes. We seek to gain further understanding of both the mechanisms that govern mitochondrial function, and how changes to mitochondrial function impact on a wide spectrum of metabolic health and disease including metabolic-associated diseases such as obesity and type 2 diabetes, but also cancer, exercise capacity, cardiometabolic health and longevity. In addition, therapeutic treatments that target mitochondrial mechanisms and processes will be of interest in this special collection.

The topics include but are not limited to:
• Bioenergetics
• Mitochondrial regulation
• Mitochondrial redox biology
• Mitochondrial structural remodelling and dynamics
• Mitophagy
• Mitochondrial disease
• Mitochondrial biogenesis
• Mitochondrial genome
• Interventions targeting mitochondria