Cell Research

Collection 15 March 2023

Editor’s selections: top articles from the past 3 years

Cell Research is proud to present a collection of featured articles from the last 3 years that represent a broad scope in basic molecular and cell biology research.

2023

NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos
- Fangnong Lai
- Lijia Li
- Wei Xie
ArticleOpen Access7 Nov 2023 Cell Research
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
- Rui Liu
- Lin-Wen Zeng
- Shu Li
ArticleOpen Access6 Nov 2023 Cell Research
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
- Yu-Qing Wu
- Chen-Song Zhang
- Sheng-Cai Lin
ArticleOpen Access19 Sep 2023 Cell Research
Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex
- Shuqi Dong
- Huadong Li
- Jun He
ArticleOpen Access4 Sep 2023 Cell Research
HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation
- Erpeng Wu
- Wenyan He
- Liming Sun
ArticleOpen Access14 Aug 2023 Cell Research
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
- Runshuai Zhang
- Jinan Fang
- Lianfeng Wu
ArticleOpen Access27 Jul 2023 Cell Research
Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
- Zongyong Ai
- Baohua Niu
- Tianqing Li
ArticleOpen Access17 Jul 2023 Cell Research
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
- Yuan-li Ai
- Wei-jia Wang
- Qiao Wu
ArticleOpen Access17 Jul 2023 Cell Research
The complete and fully-phased diploid genome of a male Han Chinese
- Chentao Yang
- Yang Zhou
- Guojie Zhang
ArticleOpen Access14 Jul 2023 Cell Research
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
- Naijin Zhang
- Ying Zhang
- Yingxian Sun
ArticleOpen Access13 Jul 2023 Cell Research
An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk, local immunosuppression and tumor progression
- Liang Wu
- Jiayan Yan
- Jian Zhou
ArticleOpen Access19 Jun 2023 Cell Research
Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity
- Xiaoshen Wang
- Xuzichao Li
- Heng Zhang
ArticleOpen Access13 Jun 2023 Cell Research
A direct spino-cortical circuit bypassing the thalamus modulates nociception
- Bing Cai
- Dan Wu
- Xu Zhang
ArticleOpen Access13 Jun 2023 Cell Research
Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
- Xinwei Wang
- Mu Wang
- Beili Wu
ArticleOpen Access8 Jun 2023 Cell Research
Structural genomics of the human dopamine receptor system
- Peiyu Xu
- Sijie Huang
- H. Eric Xu
Article23 May 2023 Cell Research
Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing
- Christopher C. Pan
- Raquel Maeso-Díaz
- Xiao-Fan Wang
Article11 May 2023 Cell Research
Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies
- Liang Guo
- Qionglei Mao
- Yichang Jia
ArticleOpen Access4 May 2023 Cell Research
Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage
- Shangtao Cao
- Huijian Feng
- Yanlin Ma
ArticleOpen Access21 Apr 2023 Cell Research
Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse
- Tingting Song
- Wusa Qin
- Rui Huang
ArticleOpen Access13 Apr 2023 Cell Research
A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis
- Hongdi Ma
- Taidou Hu
- Shu Zhu
ArticleOpen Access13 Apr 2023 Cell Research
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
- Jian Chen
- Shizhen Qiu
- Haopeng Wang
ArticleOpen Access8 Mar 2023 Cell Research
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression
- Shiqiao Qiu
- Xiuying Zhong
- Ping Gao
Article2 Mar 2023 Cell Research
Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796
- Aijun Long
- Yang Liu
- Yiguo Wang
Article17 Feb 2023 Cell Research
Mechanism of activation and biased signaling in complement receptor C5aR1
- Yuying Feng
- Chang Zhao
- Zhenhua Shao
ArticleOpen Access17 Feb 2023 Cell Research
Human IFT-A complex structures provide molecular insights into ciliary transport
- Meiqin Jiang
- Vivek Reddy Palicharla
- Ji Sun
ArticleOpen Access13 Feb 2023 Cell Research
SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses
- Shufen Li
- Yulan Zhang
- Ke Peng
Article17 Jan 2023 Cell Research
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation
- Ao Sun
- Cheng-Ping Li
- Jun-Jie Gogo Liu
Article17 Jan 2023 Cell Research
Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria
- Xiao-Qing Xie
- Yi Yang
- Xiu-Wu Bian
ArticleOpen Access10 Jan 2023 Cell Research
LilrB3 is a putative cell surface receptor of APOE4
- Jiayao Zhou
- Yumeng Wang
- Yigong Shi
Article2 Jan 2023 Cell Research
Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1
- Ping Luo
- Wenbo Feng
- Yi Jiang
Article2 Jan 2023 Cell Research

2022

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
- Wei Pang
- Ying Lu
- Yong-Tang Zheng
ArticleOpen Access10 Nov 2022 Cell Research
Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors
- Fan Zhang
- Qilin Zhang
- Yao Zhao
ArticleOpen Access28 Oct 2022 Cell Research
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity
- Ying Gao
- Xueping Zheng
- Tiebang Kang
ArticleOpen Access24 Oct 2022 Cell Research
A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers
- Rongjie Cheng
- Fanying Li
- Nu Zhang
ArticleOpen Access14 Oct 2022 Cell Research
Cryo-EM structures of human m⁶A writer complexes
- Shichen Su
- Shanshan Li
- Kaiming Zhang
ArticleOpen Access27 Sep 2022 Cell Research
Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study
- Yongxian Hu
- Yali Zhou
- He Huang
Article23 Sep 2022 Cell Research
CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification
- Xin-Yuan Lyu
- Yuan Deng
- Chun-Qing Song
ArticleOpen Access14 Sep 2022 Cell Research
Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron
- Huan Ma
- Xinghai Zhang
- Tengchuan Jin
ArticleOpen Access29 Jul 2022 Cell Research
Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis
- Hong-Guang Zhang
- Bin Wang
- Hui Zheng
Article12 Jul 2022 Cell Research
A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL
- Yuteng Weng
- Haicheng Wang
- Zuolin Wang
ArticleOpen Access12 Jul 2022 Cell Research
A super pan-genomic landscape of rice
- Lianguang Shang
- Xiaoxia Li
- Qian Qian
ArticleOpen Access12 Jul 2022 Cell Research
CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation
- Chao Wei
- Lumeng Jia
- Junjun Ding
Article29 Jun 2022 Cell Research
Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans
- Wei Wang
- Mengdi Wang
- Xiaoqun Wang
Article24 Jun 2022 Cell Research
Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response
- Wanjin Li
- Bing Shan
- Junying Yuan
Article3 Jun 2022 Cell Research
Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish
- Boyang Shi
- Jian Heng
- Yun-Gui Yang
Article3 Jun 2022 Cell Research
Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins
- Youwei Xu
- Canrong Wu
- Wanchao Yin
ArticleOpen Access31 May 2022 Cell Research
Derivation of totipotent-like stem cells with blastocyst-like structure forming potential
- Yaxing Xu
- Jingru Zhao
- Hongkui Deng
ArticleOpen Access4 May 2022 Cell Research
Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation
- Chenfei Wang
- Chuan Chen
- Shaorong Gao
ArticleOpen Access15 Apr 2022 Cell Research
Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex
- Gaoxingyu Huang
- Xiechao Zhan
- Yigong Shi
ArticleOpen Access18 Mar 2022 Cell Research
Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex
- Zongqiang Li
- Shuaijiabin Chen
- Sen-Fang Sui
ArticleOpen Access18 Mar 2022 Cell Research
Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing
- Ziqi Zhao
- Dan Zhang
- Zhiheng Xu
ArticleOpen Access10 Mar 2022 Cell Research
EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription
- Xiaoqing Lu
- Liwei An
- Hongxia Wang
Article23 Feb 2022 Cell Research
Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex
- Gaoxingyu Huang
- Xiechao Zhan
- Yigong Shi
ArticleOpen Access17 Feb 2022 Cell Research
Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response
- Jingjing He
- Xinxin Xiong
- Penghui Zhou
Article14 Feb 2022 Cell Research
Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects
- Qiansen Zhang
- Yimin Ren
- Ruotian Jiang
Article3 Feb 2022 Cell Research
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer
- Yi Xiao
- Ding Ma
- Yi-Zhou Jiang
ArticleOpen Access1 Feb 2022 Cell Research
Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals
- Siyuan Hou
- Zongcheng Li
- Yu Lan
ArticleOpen Access25 Jan 2022 Cell Research
A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs
- Zezhong Liu
- Jie Zhou
- Lu Lu
ArticleOpen Access19 Jan 2022 Cell Research
Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response
- Xiaochen Gai
- Di Xin
- Xiaochun Yu
Article4 Jan 2022 Cell Research

2021

Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2
- Yunqing Gu
- Jun Cao
- Zhigang Lu
Article26 Nov 2021 Cell Research
Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2
- Shaojun Zhang
- Wenze Huang
- Qiangfeng Cliff Zhang
ArticleOpen Access4 Nov 2021 Cell Research
Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms
- Rongjia Zhu
- Tingdong Yan
- Robert Chunhua Zhao
ArticleOpen Access26 Oct 2021 Cell Research
SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation
- Gang Xu
- Ying Li
- Junying Yuan
ArticleOpen Access18 Oct 2021 Cell Research
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
- Nicolas A. Heyder
- Gunnar Kleinau
- Patrick Scheerer
ArticleOpen Access24 Sep 2021 Cell Research
A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis
- Shulin Li
- Rui Yan
- Liang Ge
Article24 Sep 2021 Cell Research
Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition
- Yuan Yuan
- Guowen Jia
- Zhenhua Shao
Article15 Sep 2021 Cell Research
Structural insights into ligand recognition and activation of the melanocortin-4 receptor
- Huibing Zhang
- Li-Nan Chen
- Yan Zhang
Article25 Aug 2021 Cell Research
Degradation of lipid droplets by chimeric autophagy-tethering compounds
- Yuhua Fu
- Ningxie Chen
- Boxun Lu
ArticleOpen Access8 Jul 2021 Cell Research
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling
- Xiao-Ning Zhang
- Kai-Di Yang
- Yi-Fang Ping
ArticleOpen Access8 Jul 2021 Cell Research
A cohort autopsy study defines COVID-19 systemic pathogenesis
- Xiao-Hong Yao
- Tao Luo
- Xiu-Wu Bian
ArticleOpen Access16 Jun 2021 Cell Research
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
- Bingqing Xia
- Xurui Shen
- Zhaobing Gao
ArticleOpen Access10 Jun 2021 Cell Research
RNA m⁶A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability
- Feng Xiong
- Ruoyu Wang
- Wenbo Li
ArticleOpen Access9 Jun 2021 Cell Research
Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines
- Yunlong Cao
- Ayijiang Yisimayi
- Xiaoliang Sunney Xie
ArticleOpen Access21 May 2021 Cell Research
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
- Jia-yuan Zhang
- Bo Zhou
- Qiao Wu
ArticleOpen Access19 May 2021 Cell Research
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics
- Zheng Fu
- Xiang Zhang
- Xi Chen
ArticleOpen Access29 Mar 2021 Cell Research
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies
- Renhong Yan
- Ruoke Wang
- Qiang Zhou
ArticleOpen Access17 Mar 2021 Cell Research
Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures
- Lei Sun
- Kui Xu
- Qiangfeng Cliff Zhang
ArticleOpen Access23 Feb 2021 Cell Research
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation
- Xiaoxiao Wang
- Yunlong Xiang
- Lei Li
ArticleOpen Access19 Feb 2021 Cell Research
Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca²⁺ ions and L-tryptophan
- Shenglong Ling
- Pan Shi
- Changlin Tian
ArticleOpen Access18 Feb 2021 Cell Research
Coinfection with influenza A virus enhances SARS-CoV-2 infectivity
- Lei Bai
- Yongliang Zhao
- Ke Xu
Article18 Feb 2021 Cell Research
Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome
- J. Yuyang Lu
- Lei Chang
- Xiaohua Shen
ArticleOpen Access29 Jan 2021 Cell Research
The m⁶A methylome of SARS-CoV-2 in host cells
- Jun’e Liu
- Yan-Peng Xu
- Cheng-Feng Qin
ArticleOpen Access28 Jan 2021 Cell Research
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages
- Els Wauters
- Pierre Van Mol
- Diether Lambrechts
ArticleOpen Access21 Jan 2021 Cell Research
Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses
- Jian He
- Jing Yan
- Rui Yue
ArticleOpen Access20 Jan 2021 Cell Research
AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells
- Shuai Wang
- Zongyang Qiu
- Xu Li
ArticleOpen Access8 Jan 2021 Cell Research
Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration
- Molong Qu
- Liang Xiong
- Hongkui Deng
ArticleOpen Access8 Jan 2021 Cell Research

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