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Alzheimer’s disease

Hearing loss promotes Alzheimer’s disease

Nature Aging volume 4, pages 443–444 (2024)Cite this article

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Epidemiological studies reveal a correlation between hearing loss and the development and progression of Alzheimer’s disease (AD), but the underlying causal mechanisms remain unclear. A study now provides experimental evidence that hearing loss can promote AD via the growth differentiation factor 1 (GDF1) pathway, which may aid in developing potential AD therapeutic strategies.

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Fig. 1: Hearing loss promotes AD via the GDF1-mediated AKT signaling pathway.

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Acknowledgements

H.-B.Z. is supported by NIH RF1 AG082216 and R01 AG080587.

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  1. Department of Surgery – Otolaryngology, Yale University Medical School, New Haven, CT, USA

    Hong-Bo Zhao & Yang Yang

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  1. Hong-Bo Zhao
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  2. Yang Yang
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Correspondence to Hong-Bo Zhao.

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The author declares no competing interests.

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Zhao, HB., Yang, Y. Hearing loss promotes Alzheimer’s disease. Nat Aging 4, 443–444 (2024). https://doi.org/10.1038/s43587-024-00606-2

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