The extracellular matrix is an essential component of the tumor microenvironment and affects cancer progression. Weeraratna and colleagues have now uncovered that age-related reductions in the level of hyaluronan and proteoglycan link protein 1 (HAPLN1) stimulate neoangiogenesis and compromise the vascular integrity of intratumoral blood vessels. These biological modifications converge to fuel distant melanoma metastasis.
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Acknowledgements
C.B. was supported by the French government, INSERM and La Ligue Nationale contre le cancer.
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Bertolotto, C. Mechanisms of melanoma aggressiveness with age. Nat Aging 4, 287–288 (2024). https://doi.org/10.1038/s43587-024-00574-7
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DOI: https://doi.org/10.1038/s43587-024-00574-7