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Efficient epigenetic clock measurements with TIME-seq

Nature Aging volume 4, pages 175–176 (2024)Cite this article

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Tagmentation-based methylation sequencing (TIME-seq) is an efficient and cost-effective solution for measuring and generating epigenetic clocks. We applied TIME-seq to over 2,800 mouse and human DNA samples to produce clocks that demonstrate accuracy and robustness; the method also outperforms conventional methods in speed and cost. The simple and practical design of TIME-seq facilitates large-scale epigenetic clock analysis, which makes it a valuable tool for advancing aging research.

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Fig. 1: TIME-seq enables scalable and affordable large-scale epigenetic clock measurement.

References

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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

P.T.G. and D.A.S. used ChatGPT to help prepare their contribution to this Research Briefing.

This is a summary of: Griffin, P. T. et al. TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction. Nat. Aging, https://doi.org/10.1038/s43587-023-00555-2 (2024).

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Efficient epigenetic clock measurements with TIME-seq. Nat Aging 4, 175–176 (2024). https://doi.org/10.1038/s43587-023-00559-y

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