Neuronal aging is highly associated with misfolded protein aggregates that predispose to neurodegeneration, but the cellular factors that are involved in removing misfolded proteins are yet to be identified. In this issue of Nature Aging, Li and colleagues identified LONRF2 as an important player in protecting aging neurons against the accumulation of protein aggregates.
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Youssef, M.M.M., Park, J. LONRF2 is a gatekeeper against protein aggregation in aging neurons. Nat Aging 3, 913–914 (2023). https://doi.org/10.1038/s43587-023-00457-3
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DOI: https://doi.org/10.1038/s43587-023-00457-3