By applying deep molecular profiling to our long-term mouse parabiosis model, we reveal reduced epigenetic age in old mice that shared circulation with young mice. The rejuvenation effect is sustained at two months after detachment, leading to lifespan extension and improved physical function, and is associated with rejuvenated transcriptomic signatures.
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References
McCay, C. M., Pope, F. & Lunsford, W. Experimental prolongation of the life span. Bull. NY Acad. Med. 32, 91–101 (1956). One of the first publications using the parabiosis model to study aging.
Conboy, I. M. et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433, 760–764 (2005). A study that shows the rejuvenating effects of heterochronic parabiosis across multiple aged tissues.
Villeda, S. A. et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat. Med. 20, 659–663 (2014). A study that shows that systemic delivery of young plasma can recapitulate the beneficial effects of parabiosis on cognition.
Baht, G. S. et al. Exposure to a youthful circulation rejuvenates bone repair through modulation of beta-catenin. Nat. Commun. 6, 7131 (2015). This study demonstrated enhanced bone repair with heterochronic parabiosis.
Poganik, R. J. et al. Biological age is increased by stress and restored upon recovery. Cell Metab. 35, 807–820 (2023). This paper establishes that biological age reversibly increases in young animals upon heterochronic parabiosis.
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This is a summary of: Zhang, B. et al. Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation. Nat. Aging https://doi.org/10.1038/s43587-023-00451-9 (2023).
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Prolonged heterochronic parabiosis decreases biological age and promotes longevity in old mice. Nat Aging 3, 917–918 (2023). https://doi.org/10.1038/s43587-023-00452-8
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DOI: https://doi.org/10.1038/s43587-023-00452-8
