Warde and colleagues demonstrate sex-specific differences in senescence in the adrenal glands of aged mice, with males eliciting a more robust, protective myeloid response that is associated with protection from adrenal cancer.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Austad, S. N. Gend. Med. 3, 79–92 (2006).
Warde, K. M. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00420-2 (2023).
Campisi, J. & d’Adda di Fagagna, F. Nat. Rev. Mol. Cell Biol. 8, 729–740 (2007).
Faget, D. V., Ren, Q. & Stewart, S. A. Nat. Rev. Cancer 19, 439–453 (2019).
Childs, B. G., Durik, M., Baker, D. J. & van Deursen, J. M. Nat. Med. 21, 1424–1435 (2015).
Berthon, A. et al. Hum. Mol. Genet. 19, 1561–1576 (2010).
Heaton, J. H. et al. Am. J. Pathol. 181, 1017–1033 (2012).
Stanworth, R. D. & Jones, T. H. Clin. Interv. Aging 3, 25–44 (2008).
Altieri, P. et al. J. Am. Heart Assoc. 5, e002383 (2016).
O’Connor, K. A. et al. Menopause 16, 1178–1187 (2009).
Crandall, C. J., Mehta, J. M. & Manson, J. E. J. Am. Med. Assoc. 329, 405–420 (2023).
Sasaki, Y. et al. J. Am. Heart Assoc. 10, e019310 (2021).
Atif, F., Yousuf, S., Espinosa-Garcia, C., Sergeeva, E. & Stein, D. G. Sci. Rep. 9, 988 (2019).
Nagy, L., Szanto, A., Szatmari, I. & Széles, L. Physiol. Rev. 92, 739–789 (2012).
Hamilton, J. A. G. & Henry, C. J. Aging Cancer 1, 30–44 (2020).
Acknowledgements
We thank A. A. Henry and C. C. Porter for their review of an early draft of this work.
Author information
Authors and Affiliations
Contributions
A.T. assisted with the drafting of this manuscript, reviewed the manuscript and created the original Fig. 1. C.J.H. conceptualized the format of this article, drafted the article, assisted with the design of the original Fig. 1 and approved the final draft of this work.
Corresponding author
Ethics declarations
Competing interest
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Townsel, A., Henry, C.J. Sex, aging, immunity and adrenal cancer. Nat Aging 3, 764–765 (2023). https://doi.org/10.1038/s43587-023-00440-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43587-023-00440-y