Aging is known to be associated with a decline in memory and mood, but the molecular mechanisms that underlie these changes remain unclear. Moigneu, Abdellaoui and colleagues show that growth differentiation factor 11 reverses deficits in these functions in aged mice, pointing the way towards a novel pro-mnemonic and antidepressant therapeutic target.
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P.P. and A.H. are supported by the NIAAA Intramural Research Program.
The authors declare no competing interests.
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Piantadosi, P.T., Holmes, A. GDF11 reverses mood and memory declines in aging. Nat Aging 3, 148–150 (2023). https://doi.org/10.1038/s43587-023-00362-9