A new study shows that decreased cystatin A synthesis in aged epidermis mediates age-related bone loss, whereas topical treatment that restores cystatin A mitigates this loss. This report demonstrates that skin aging has systemic consequences by showing that signals originating in skin can control bone function.
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Mauro, T., Bikle, D. Skin and bone crosstalk during aging. Nat Aging 2, 874–875 (2022). https://doi.org/10.1038/s43587-022-00295-9
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DOI: https://doi.org/10.1038/s43587-022-00295-9