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BRAIN AGING

Astrocytic traffic jams in the aging brain

Lee and colleagues reveal a previously unrecognized population of astrocytes in the aged brain with disrupted proteostatic signaling that generates defects in astrocyte morphology, protein trafficking and synapse maintenance in the aging hippocampus.

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Fig. 1: A genetically and functionally unique population of hippocampal astrocytes stemming from reduced astrocytic mTOR and proteasome activity appears with advancing age.

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Correspondence to Cagla Eroglu.

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Baumert, R., Brose, N. & Eroglu, C. Astrocytic traffic jams in the aging brain. Nat Aging 2, 681–683 (2022). https://doi.org/10.1038/s43587-022-00270-4

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